摘要
目的 观察托毗酯联合丙戊酸钠治疗婴儿痉挛的临床疗效.方法 将40例婴儿痉挛患儿,随机分为对照组和治疗组,每组各20例.对照组采用常规丙戊酸钠口服的治疗方法 治疗组采用托吡酯联合丙戊酸钠治疗.连续治疗3个月后比较两组的临床疗效和脑电图改善情况.结果 治疗组总有效率（95.0%）、脑电图改善情况（90.0%）均优于对照组的（70.0%和60.0%）（x2=4.32,4.80,均P〈0.05）.结论 托吡酯添加治疗婴儿痉挛症不良反应较少,临床效果良好.
Objective To observe the clinical effects of topiramate combined with sodium valproate in treatment of infantile spasms.Methods 40 children with infantile spasms were randomly divided into control group and treatment group,each group 20 patients.The control group was treated with sodium valproate.The treatment group received topiramate combined with sodium valproate.The two groups were all treated for 3 months.Results The total effective rate and electroencephalogram improvement of the treatment group was 95.0% ,90.0% respectively,and significantly better than those of the control group （ 70.0% , 60.0% respectively ） （ x2 = 4.32,4.80, all P 〈 0.05 ）.Conclusion The therapeutic effect of topiramate combined with sodium valproate in treatment of infantile spasms was good and worthy of being widely used in clinic.
出处
《中国基层医药》
CAS
2011年第12期1645-1646,共2页
Chinese Journal of Primary Medicine and Pharmacy
关键词
痉挛
婴儿
托吡酯
丙戊酸钠
Spasms, infant Topiramate Sodium valproate
