摘要
目的 观察抗结核药联合大剂量糖皮质激素冲击疗法治疗晚期结核性脑膜炎的临床疗效和安全性.方法 77例晚期结核性脑膜炎患者在知情同意下随机分为观察组39例和对照组38例,两组均给予规范的抗结核治疗,对照组加用地塞米松20 mg/d,静脉滴注,至患者症状明显改善后减量;观察组给予甲泼尼龙500 mg/d,静脉滴注,冲击治疗5 d后,改为80 mg/d,并逐渐减量至维持剂量.两组疗程均为3个月,观察比较两组临床疗效及不良反应发生情况.结果 治疗3个月后,观察组治愈32例、有效6例、无效1例、总有效率97.4%,对照组分别为22例、8例、8例、78.9%,两组总有效率差异有统计学意义（x2=7.57,P＜0.05）.观察组意识恢复时间（2.7±1.3）d、发热时间（13±5）d、脑脊液白细胞计数（112.37±27.57）× 106/L、脑脊液蛋白含量（3.04±0.82）g/L、脑脊液氯化物（32.7 ±6.4）mmol/L、脑脊液葡萄糖（1.67±0.65）mmol/L,对照组分另为（5,2±2.4）d、（19±6）d、（93.74±20.18）×106/L、（1.92±0.64）g/L、（25.4±5.2）mmol/L、（1.04±0.34）mmol/L,两组差异均有统计学意义（t=5.70、4.77、3.88、6.67、5.48、5.31,均P＜0.01）.两组不良反应发生率差异无统计学意义（P＞0.05）.结论 抗结核药联合大剂量糖皮质激素冲击疗法治疗晚期结核性脑膜炎具有显著临床疗效,能迅速改善患者症状和体征,且不良反应无明显增加,值得临床推广.
Objective To observe the clinical efficacy and security of anti-tuberculosis combined with highdose methylprednisolone in treatment of advanced tuberculous meningitis.Methods 77 patients with advanced tuberculous meningitis in our department were randomly divided into the observation group（39 cases）and the control group （38 cases）.All of the patients were given initiate antiphthisie treatment,the control group were added dexamethasone,20mg/d,iv drip,then was maintained after improved;the observation group were added high-dose methyprednisolone（500mg/d）by intravenous injection for five days,then was given methyprednisolone 80mg/d to maintain.Two groups were treated with hormone no more than three months.Then the clinical efficacy and adveme reaction were compared.Results The observation group：32 cases of healing,6 cases of effective,1 case of inefficient,the total effective rate was 97.4%and the control group were 22,8,8,78.9%;the difference of total effective rates in the two groups was statistically significant（x2=7.57,P＜0.05）.The time of consciousness restoration and defevesence,the white blood cell count,protein chloride and glucose content of cerebrospinal fluid of the observation group were（2.7±1.3）d,（13±5）d,（112.37±27.57）×106/L,（3.04±0.82）g/L,（32.7±6.4）mmol/L and（1.67±0.65）mmol/L;and the control group were（5.2±2.4）d,（19±6）d,（93.74±20.18）×106/L,（1.92±0.64）g/L,（25.4 ±5.2）mmol/L and（1.04±0.34）mmol/L,the difference was statistically significant（t=5.70,4.77,3.88,6.67,5.48,5.31,P＜0.01）;The difference of adverse reaction rate between the two groups was not statistically significant （P＜0.05）.Conclusion The clinical efficacy of anti-tuberculosis combined with high-dose methylprednisolone in treatment of advanced tuberculous meningitis was better and had advantages in improving symptoms and signs without enhancing the rate of adverse reaction and it was worth to promote in clinical.
出处
《中国基层医药》
CAS
2011年第11期1460-1461,共2页
Chinese Journal of Primary Medicine and Pharmacy
关键词
脑膜脑炎
糖皮质激素类
冲击疗法
Meningoencephalitis
Glucocorticoids
Shock treatment
