摘要
目的 研究2型糖尿病（T2DM）患者肿瘤坏死因子-α（TNF-α）、白细胞介素-6（IL-6）和脂联素与胰岛素抵抗的关系.方法 选择80例T2DM患者（T2DM组）和40例健康体检者（对照组）,测定各组空腹血清TNF-α,IL-6和脂联素水平,同时分别测定各组患者体质量指数（BMI）、空腹血糖、血清胰岛素水平,计算胰岛素抵抗指数（HOMA-IR）.结果 T2DM组TNF-α、IL-6水平均明显高于对照组,脂联素水平明显低于对照组（均P＜0.05）.在T2DM组中,TNF-α和IL-6均与HOMA-IR呈正相关（P＜0.01,P＜0.05）,脂联素与HOMA-IR呈负相关（P＜0.01）.结论 IL-6、TNF-α及脂联素参与了2型糖尿病的发病过程,与胰岛素抵抗密切相关.
Objective To explore the relationships between Serum levels of tumor necrosis factor-alpha TNFα,1L-6,adiponectin and insulin resistance in type 2 diabetes.Methods 80 T2DM patients and 40 healthy controls were recruited.Levels of serum TNF-α,IL-6,adiponectin,plasma glucose,insulin and BMI were measured.Insulin resistance was evaluated by HOMA-IR.Results The levels of TNF-α and IL-6 in T2DM group were significantly higher than that in control group（all P＜0.05）;The levels of adiponeetin in T2DM group was significantly lower than that in control group（P＜0.05）.The levels of TNF-α and IL-6 were positively correlated with HOMA-IR（P＜0.05）,adiponeetin was egatively correlated nwith HOMA-IR（P＜0.01）.Conclusion TNF-α,IL-6 and adiponectin were closely related with insulin resistance,and should take parts in development of T2DM.
出处
《中国基层医药》
CAS
2011年第10期1308-1309,共2页
Chinese Journal of Primary Medicine and Pharmacy
关键词
糖尿病
2型
胰岛素抵抗
细胞因子
脂联素
Diabetes mellitus,type 2
Insulin resistance
Cytokines
Adiponectin
