摘要
目的:观察序贯疗法治疗胃溃疡(GU)合并幽门螺杆菌(Hp)感染的疗效以及吸烟对Hp根除的影响。方法:选择依靠胃幽门螺杆菌快速检测试纸确诊Hp(+)的85例患者,分为两组。传统三联疗法组:奥美拉唑20 mg,克拉霉素0.5 g,阿莫西林1 g,均为每天2次;序贯疗法组:前5 d奥美拉唑20 mg,每天2次,阿莫西林1 g,每天2次;后5 d加用克拉霉素500 mg,每天2次,甲硝唑400 mg,每天2次,疗程共10 d。对比两组疗效,并观察两组中吸烟患者对Hp根除的影响。结果:传统三联疗法组溃疡Hp根除率81.0%,序贯疗法组Hp根除率90.7%,两组比较差异有统计学意义。646例吸烟者中治疗时继续吸烟者与戒烟者Hp根除率分别为50.00%和89.47%。结论:序贯疗法根除Hp的效果较好。吸烟可以影响Hp的根除率。
Objective：To observe the curative effect of sequential therapy in treatment of gastric ulcer combined with Helicobacter pylori（Hp） infection and the influence of smoking on Hp eradication.Methods：Eighty-five patients with Hp（＋） confirmed by the rapid detection strip of Helicobacter pylori were divided into two groups.The traditional triple-therapy group was treated with Omeprazole 20 mg,Clarithromycin 0.5 g and Amoxicillin 1 g and all were treated twice per day.The sequential therapy group was treated with Omeprazole 20 mg（twice per day）,Amoxicillin 1 g（twice per day） at the first 5 days and added with Clarithromycin 500 mg（twice per day） and Metronidazole 400 mg（twice per day） at the last 5 days.The course of treatment continued for 10 days to compare the curative effect and observe the influence of the smokers on Hp eradication in the two groups.Results：The eradication rate in the traditional triple-therapy group was 81.0% and that in the sequential therapy group was 90.7%.There was statistical significance comparing between the two groups.The eradication rate of the smokers and the smoking quitters during the treatment was 50.00% and 89.47% respectively among 646 smokers.Conclusion：Sequential therapy is more effective in Hp eradication especially in that of smoking quitters.Smoking may affect the eradication rate of Helicobacter pylori.
出处
《山西职工医学院学报》
CAS
2011年第2期6-8,共3页
Journal of Shanxi Medical College for Continuing Education
关键词
胃溃疡
幽门螺杆菌感染
序贯疗法
传统三联疗法
HP根除率
吸烟
gastric ulcer
Helicobacter pylori infection
sequential therapy
traditional triple-therapy
Hp eradication rate
smoking
