摘要
目的：探讨高原低氧环境下外周血肿瘤坏死因子（ Ｔ Ｎ Ｆ－ α） 和白细胞介素－ ６（ Ｉ Ｌ－ ６） 水平的变化及其意义。方法：对从平原进驻海拔３ ７００ ｍ 和５ ３８０ ｍ 高原第７ ｄ 和半年的健康青年，应用放射免疫分析法测定血清 Ｔ Ｎ Ｆ－ α和 Ｉ Ｌ－ ６ ，并与平原（ 海拔１ ４００ ｍ） 健康青年作对照。结果：高原低氧环境 Ｔ Ｎ Ｆ－ α和 Ｉ Ｌ－ ６ 水平明显高于平原（ Ｐ＜ ０ ．０５ 或 Ｐ＜ ０ ．０１） ，且随海拔高度的升高而增高（ Ｐ＜ ０ ．０１） ，随居住时间的延长而降低（ Ｐ＜ ０ ．０５ 或＜ ０ ．０１） 。结论： Ｔ Ｎ Ｆ－ α和 Ｉ Ｌ－ ６ 参与了机体急、慢性低氧的应激过程，诱导体内免疫细胞因子网络系统处于激活状态。
Purpose:To investigate the changes and significance of peripheral blood tumour necrosis factor-α(TNF-α) and interleukine-6(IL-6) levels in high elevation hypoxia environment. Methods:The peripheral blood TNF-αand IL-6 levels were examinated by RIA in healthy youths who arrived the elevations of 3 700 m and 5 380 m after 7 days and 6 months,and those of healthy youths inhabited in plain were used as controls. Results:The TNF-α and IL-6 levels were higher in high elevation hypoxia environment than those in plain group( P <0.05 or P <0.01),and they increased with the rising of elevation( P <0.01) and reduced with the lengthening or inhabited time( P <0.05 or P <0.01). Conclusion:TNF-α and IL-6 participate the process of body stress for acute or chronic hypoxia,and in the meanwhile,induce and activate the network-system of immune factor.
出处
《西北国防医学杂志》
CAS
1999年第3期197-198,共2页
Medical Journal of National Defending Forces in Northwest China
关键词
高原
肿瘤坏死因子
白细胞介素6
High elevation
Tumour necrosis factor-α(TNF-α)
Interleukine-6(IL-6)
