摘要
目的:研究建立面肌痉挛的动物模型的方法,并探讨其发病机制。方法:采用颞浅动脉压迫已人为脱髓鞘变的周围面神经主干,在新西兰大白兔上复制面肌痉挛动物模型,并通过电生理技术检测面肌痉挛所特有的异常肌反应(AMR)。结果:于术后第6周在模型组动物上成功地诱发出AMR,其潜伏期为(8.00±0.55)ms。结论:面神经脱髓鞘变和血管压迫是引起面肌痉挛的两个必要条件。
Aim: To study the method of making the animal model of hemifacial spasm and its pathogene-sis. Methods: The animal models of hemifacial spasm in New Zealand white rabbits were established by compressing the main trunk of artificial demyelinated facial nerve with the temporal superficial artery. The elec-trophysiological technique was used to explore abnormal muscle response (AMR) which is characteristic for hemifacial spasm. Results: A clear AMR was evoked in model group at the sixth week after operation with a latency of 8. 00±0. 55 ms. Conclusion:The facial nerve demyelination and vascular compression are both needed to induce hemifacial spasm essentially.
出处
《中国临床神经科学》
1999年第3期151-153,共3页
Chinese Journal of Clinical Neurosciences
关键词
面肌痉挛
发病机制
动物模型
HFS
hemifacial spasm vascular compression demyelination pathogenesis animal model
