摘要
目的 探讨角质形成细胞异常增生的发病机理。方法 通过外源性底物磷酸化方法，测定了１６ 例正常皮肤、２２ 例银屑病皮损、５ 例皮肤鳞癌组织角质形成细胞膜酪氨酸蛋白激酶（ Ｔ Ｐ Ｋ） 的活性。结果 角质形成细胞膜 Ｔ Ｐ Ｋ 活性在银屑病和癌组织中显著增高，且癌组织又明显高于银屑病皮损。结论 提示 Ｔ Ｐ Ｋ 活性的异常可能在角质形成细胞的异常增生中起重要作用。
Objective To study the pathogenesis of abnormal proliferation of keratinocytes.Method The activity of tyrosine protein kinase(TPK) was determined by using exogenic substrates in 16 samples of normal skin,22 psoriatic lesion and 5 skin squamous carcinoma.Result The activity of TPK was significntly increased in psoriatic lesion and skin squamous carcinoma,and even higher in carcinoma.Conclusion The increased activity of TPK may play an important role in keratinocyte hyperproliferation.
出处
《中国皮肤性病学杂志》
CAS
北大核心
1999年第5期261-262,共2页
The Chinese Journal of Dermatovenereology
关键词
银屑病
皮肤鳞癌
酪氨酸蛋白激酶
Psoriasis Squamous carcinoma Tyrosine protein kinase
