摘要
目的：探讨白细胞介素－６（ＩＬ－６）、肿瘤坏死因子－α（ＴＮＦ－α）及细胞免疫在天疱疮发病机理中的作用，以及其血清浓度与病情的关系。方法：用双抗体夹心ＥＬＩＳＡ法检测了２６例寻常型天疱疮（ＰＶ）和１４例红斑型天疱疮（ＰＥ）治疗前以及８例皮损消退后血清ＩＬ－６与ＴＮＦ－α水平。结果：天疱疮患者治疗前血清中ＩＬ－６与ＴＮＦ－α含量显著高于对照组（均Ｐ＜０．０１）；两种细胞因子血浓度均与皮损面积呈正相关（均Ｐ＜０．０１），随皮损消退其含量下降（Ｐ＜０．０５）。结论：天疱疮患者血清中ＩＬ－６与ＴＮＦ－α水平与天疱疮病情活动性相关，ＩＬ－６和ＴＮＦ－α及细胞免疫可能参与了天疱疮的发病。
Objective: TotrytoelucidatetheroleofIL6,TNFandcellmediatedimmunemechanisminthepathogenesisofpemphigus,andtofindouttherelationshipbetweenthetwocytokinesandthediseaseactivity. Methods: TheserumlevelsofIL6andINFweredeterminedbydoubleantibodysandwichELISAmethodin26patientswithpemphigusvulgaris(PV),14withpemphiguserythematosis(PE)beforetreatment,andin8PVcasesafterthedisappearanceoftheskinlesions,andin23normalcontrols. Results: SerumlevelsofIL6 andTNFinpemphiguspatientsbeforetreatmentweresignificantlyhigherthanthoseinnormalcontrols(P<001).ApositivecorrelationwasfoundbetweentheserumlevelsofIL6,TNFandtheareaoflesions(P<001).Theserumlevelsofthetwocytokinesdeclinedastheskinlesionsdisappeared(P<005). Conclusion: ThereisarelationshipbetweentheserumlevelsofIL6,TNF andthediseaseactivityofpemphigus.IL6,TNFandcellmediatedimmunemechanismmayplayanimportantroleinthepathogenesisofpemphigus.
出处
《滨州医学院学报》
1999年第3期216-218,共3页
Journal of Binzhou Medical University
