摘要
目的调查2010年乌鲁木齐地区腹泻病原菌耐药性特征,为指导本地区临床合理用药提供参考。方法对腹泻标本进行细菌学培养,利用生化、血清学方法对分离菌株进行特异性鉴定。在此基础上,利用K-B纸片扩散法检测病原菌的耐药性。结果从392份腹泻标本中,分离获得病原菌103株,主要包括47株志贺菌、33株致泻性大肠埃希菌及15株沙门菌。上述病原菌普遍耐受氨苄西林,耐药率达75.7%;对β-内酰胺类、头孢菌素类和喹诺酮类等常见抗生素产生不同程度的耐药性;少数病原菌对碳青霉烯类抗生素已产生耐药性。结论志贺菌、致泻性大肠埃希菌和沙门菌是引起乌鲁木齐地区居民感染性腹泻的主要病原菌,耐药性问题突出。
Objective To investigate antimicrobial resistance of bacterial pathogens isolated from patients with seasonal diar- rhea in Urumqi so as to provide evidence for rational use of drugs. Methods Bacterial pathogens were isolated from fecal speci- mens from diarrheal patients, and identified by biochemical and serological methods. Antimicrobial resistance was tested using K-B diffuse method. Results Totally 103 pathogenic bacteria strains were isolated from 392 samples, mainly including 47 Shigella spp. strains, 33 diarrheagenic Escherichia coli strains and 15 Salmonella spp. strains. The isolated strains were generally resistant to am- plicillin with the resistance rate of 75.7%, and to a certain degree resistant to common antimicrobial agents, such as β-laetams, cephalosporins and quinolones. A few isolates were found to be resistant to carbapenems. Conclusions ShigeUa spp., diarrheapa- thogenic E. cali and Salmonella spp. are the major pathogens causing the seasonal diarrhea in Urumuqi, and severe antimicrobial re- sistance has been observed.
出处
《传染病信息》
2011年第2期85-87,共3页
Infectious Disease Information
基金
国家"十一五"科技重大专项(2009ZX10004-205)
关键词
腹泻
细菌
抗药性
diarrhea
bacteria
drug resistance
