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水凝胶在软骨组织工程中的应用 被引量：2

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摘要 成熟的关节软骨无血液供应、神经支配及淋巴回流，故软骨的自身修复能力非常有限。全厚软骨损伤在某些情况下可发生自发性修复反应，但新形成的组织是纤维性软骨组织，不具有天然透明软骨的生物化学和生物力学特征，通常会在生理负荷下发生退变^[1]。组织工程的提出及应用为关节软骨缺损的冉生修复带来了希望。水凝胶是一种以水为分散介质的高分子网络体系，性质柔软，能保持一定的形状和吸收大量的水。凡是水溶性或亲水性的高分子，通过一定的化学交联或物理交联，都可以形成水凝胶。水凝胶应用于软骨组织工程，克服了以往支架材料的许多缺陷，本文就水凝胶的部分基础研究及其在软骨组织工程中的应用做一综述。
作者 张一 杨柳
机构地区 第三军医大学附属西南医院关节外科中心
出处 《中华创伤骨科杂志》 CAS CSCD 2011年第5期478-480,共3页 Chinese Journal of Orthopaedic Trauma
基金 国家高技术研究发展计划（863训’划）临床应用分题（2006AA02A125） 全军“卜一五”医药卫生科研重点攻关课题（06G079） 国家自然科学基金资助项目（30870639）
关键词 软骨组织工程 水凝胶 应用 关节软骨缺损 生物力学特征 修复能力 血液供应 淋巴回流
分类号 R3 [医药卫生—基础医学]
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参考文献32

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同被引文献35

  • 1岳凌,杨占山,杨淑琴,潘秀花,潘鹏.含药水凝胶膜的制备及其药物释放规律的研究[J].辐射研究与辐射工艺学报,2005,23(6):355-358. 被引量：7
  • 2潘珍珍,潘陈为,陈永平.大鼠肝脏白细胞介素-1α和白细胞介素-6的表达与肝纤维化的相关性分析[J].实用医学杂志,2007,23(19):2988-2989. 被引量：3
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  • 5Solchaga LA,Penick K,Goldberg VM,et al.Fibroblast growth factor-2 enhances proliferation and delays loss of chondrogenic potential in human adult bone- marrow-derived mesenchymal stem cells.Tissue Eng Part A.2010; 16(3): 1009-1019.
  • 6Park H,Temenoff JS,Tabata ,et aI.Effect of dual growth factor delivery on chondrogenic differentiation of rabbit marrow mesenchymal stem cells encapsulated in injectable hydrogel composites.J Biomed Mater Res A.2009;88(4):889-897.
  • 7Zhang Y, Wang F, Chen J,et aI.Bone marrow-derived mesenchymal stem cells versus bone marrow nucleated cells in the treatment of chondral defects.lnt Orthop. 2012;36(5): 1079-1086.
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  • 9Cacchiarelli D,Martone J,Girardi E,et al. MicroRNAs involved in molecular circuitries relevant for the Duchenne muscular dystrophy pathogenesis are controlled by the dystrophin/nNOS pathway.Cell Metab 2010; 12(4):341-351.
  • 10McCarthy JJ,Esser KA, Peterson CA,et aI.Evidence of MyomiR network regulation of -myosin heavy chain gene expression during skeletal muscle atrophy. Physiol Genomics.2009;39:219-226.

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中华创伤骨科杂志
2011年 第5期

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