摘要
目的:制备双氢青蒿素-羟丙基-β-环糊精(HP-β-CD)包合物,并考察其对阴道毛滴虫的杀灭作用。方法:超声法制备双氢青蒿素HP-β-CD包合物。以紫外分光光度法和粉末X射线衍射分析法鉴定包合物的制备结果,MTT法考察双氢青蒿素的HP-β-CD包合物对阴道毛滴虫的杀灭作用。结果:紫外分光光度法与粉末X射线衍射分析均表明双氢青蒿素与HP-β-CD形成了包合物,双氢青蒿素被包合后,对阴道毛滴虫的杀灭作用与包合前有显著差异(P<0.05)。结论:双氢青蒿素-HP-β-CD包合物显著提高了双氢青蒿素的杀灭阴道毛滴虫的作用。
Objective： To prepare the water-soluble dihydroartemisinin hydroxypropyl-β-eyclodextrin inclusion complex and study its disinfection effect against trichomonas vaginalis by MTT Assay. Method： The ultrasound method has been used to prepare the inclu- sion complex. The UV and powder X-ray diffraction （PXRD） techniques have been used to identify the complex. The MTT assay has been applied to study the disinfection effect against trichomonas vaginalis. Result： The complex has been validated by UV and PXRD. There was significant difference in the disinfection effect against trichomonas vaginalis between the inclusion complex and dihydroarte- raisin （P 〈 0. 05 ）. Conclusion： The dihydroartemisinin hydroxypropyl-β-cyclodextrin inclusion complex can significantly improve the disinfection effect against Trichomonas vaginalis.
出处
《中国药师》
CAS
2011年第5期625-627,共3页
China Pharmacist
基金
北京市教育委员科技发展计划面上项目(编号:KM200910025014)
