摘要
目的 使用剑桥神经心理自动化成套测试（CANTAB）对偏执型精神分裂症与双相躁狂患者认知功能进行比较研究,为寻找认知内表型指标提供线索.方法 采用韦氏智力测试7项简版和CANTAB中的6项分测验对35例未服药、急性期偏执型精神分裂症患者、35例双相躁狂患者和30例正常对照进行测试,通过控制或不控制IQ对认知指标进行方差分析.结果 3组被试在CANTAB 6个分测验中的15个指标中有13个指标差异有显著性（F=4.71～26.71,P=0.011～0.001）,两两比较显示精神分裂症和双相躁狂组13个指标皆显著差于正常组（P＜0.05）,而两患者组之间无差异（P＞0.05）.控制IQ后,精神分裂症组、双相躁狂组、正常对照组空间工作记忆（SWM）分测验中的策略分[（36.8±3.56）分、（37.24±4.21）分、（30.33±6.24）分]、组间搜索错误数[（4｜D.86±19.97）次、（40.24±18.92）次、（15.4±17.22）次];快速视觉信息处理（RVP）测验中的正确率（0.54±0.18、0.56±0.15、0.78±0.17）;内外纬度转换（IED）测验中的外维转换期错误数[（12.43±9.96）次、（13.18±8.98）次、（4.97±6.09）次]、总错误数（已校正）[（45.26±36.36）次、（46.61±33.32）次、（14 ± 11.7）次]共5项指标3组之间差异有显著性.两两比较显示精神分裂症和双相躁狂组5项指标皆显著差于正常组（P＜0.05）,而两患者组之间差异无显著性（P＞0.05）.其余7项指标3组之间差异无显著性.双相情感障碍患者中YMRS评分与SWM测试的组间错误呈正相关（r=0.38,P=0.039）.结论 无论控制IQ与否,两组患者CANTAB认知功能测试的损害模式相似.患者组独立于IQ的受损认知指标可作为认知内表型的候选.
Objective To detect the patterns of cognitive impairment between patients with paranoid schizophrenia and patients with bipolar mania by using the Cambridge Neuropsychological Test Automated Battery （CANTAB） ,and to explore research clues for finding of cognitive endophenotype in patients with paranoid schizophrenia or bipolar mania. Methods Six CANTAB subtests and the seven subtests of the Wechsler Abbreviated Scale of Intelligence （WAIS short form） were administered to 35 patients with paranoid schizophrenia and 33 patients with bipolar mania who were drug naive experiencing an acute episode, as well as 30 healthy controls. Results Patients with paranoid schizophrenia and bipolar mania demonstrated impairments in 13 of the 15 cognitive indicators in CANTAB. After controlling IQ, both patient groups remained as significantly different from normal controls in terms of search strategy（36. 8 ±3.56,37.24 ±4. 21,30. 33 ±6.24） ,between-search errors（40. 86 ± 19.97,40.24 ± 18.92,15.4 ±17.22） on the SWM test,the proportion of hits（0.54 ±0. 18,0.56 ±0.15,0.78 ± 0.17） on the RVIP test,total errors（45.26 ±36.36,46.61 ±33.32,14 ± 11.7） and EDS errors （12.43 ±9.96, 13.18 ±8.98,4.97 ±6.09）on the IED test. Between search error in the SWM test was positively correlation with YMRS scores （ r=0.38, P=0.039） in bipolar patients. Conclusion Both patient groups demonstrated a comparable profile of cognitive impairments during active periods of their condition. The cognitive impairment index may be a discreet cognitive endophenotype overlapping the disorders.
出处
《中华行为医学与脑科学杂志》
CAS
CSCD
北大核心
2011年第5期424-427,共4页
Chinese Journal of Behavioral Medicine and Brain Science
基金
国家自然科学基金重点项Et（30530300）,“973”课题资助项目（2007CB12301）
关键词
精神分裂症
双相障碍
剑桥神经心理自动化成套测试
认知功能
Schizophrenia
Bipolar disorder
Cambridge neuropsychological test automated battery
Cognitive function
