摘要
气体分子具有重要的医疗价值,临床上吸入O2用于治疗低氧血症及危重患者,CO2用于多种皮肤病及肛肠疾病的治疗,NO用于新生儿肺动脉高压的治疗;近年研究显示,CO可用于治疗肺动脉高压、自发性高血压及器官移植,H2S治疗肺动脉高压、高血压、动脉粥样硬化及心肌缺血损伤等,气体分子医学受到了基础研究和临床应用的高度关注。
【Abstract】 Oxidative stress is intensive cellular oxidation caused by redundant reactive oxygen species（ROS） or free rad icals.RedundantROS causes DNA fracture,lipid peroxidation and protein inactivation,thus lead ing to se-vere cell damage.Recent stud ies have shown that hydrogen is a good anti-oxidant.It selectively reduces the hy-droxyl rad ical,the most cytotoxic of ROS;however,it does not react with other ROS,which play physiological roles.As a result,it could protect tissues against oxidative stress injuries,such as ischemia/reperfusion injury of the heart,liver and intestine,cisplatin nephrotoxicity,sepsis and colon inflammation.As a medical gas,hydrogen may have a prospect for far-reaching clinical application. 更多还原
【关键词】 氢； 氧化性应激； 羟自由基； 缺血； 再灌注损伤；
【Key words】 Hydrogen； Oxidative Stress； Hydroxyl rad ical； Ischem ia； Reperfusion injury；
Oxidative stress is intensive cellular oxidation caused by redundant reactive oxygen species （ROS） or free radicals. Redundant ROS causes DNA fracture, lipid peroxidation and protein inactivation, thus leading to severe cell damage. Recent studies have shown that hydrogen is a good anti-oxidant. It selectively reduces the hydroxyl radical, the most cytotoxic of ROS; however, it does not react with other ROS, which play physiological roles. As a result, it could protect tissues against oxidative stress injuries, such as ischemia/reperfusion injury of the heart, liver and intestine, cisplatin nephrotoxicity, sepsis and colon inflammation. As a medical gas, hydrogen may have a prospect for far-reaching clinical application.
出处
《北京大学学报（医学版）》
CAS
CSCD
北大核心
2011年第2期315-319,共5页
Journal of Peking University:Health Sciences
关键词
氢
氧化性应激
羟自由基
缺血
再灌注损伤
Hydrogen
Oxidative Stress
Hydroxyl radical
Ischemia
Reperfusion injury
