摘要
目的:探讨合并甲状腺功能异常的皮肌炎(dermatomyositis,DM)患者临床及免疫学特征。方法:回顾性分析70例DM患者的临床表现、肌酶水平、自身抗体、红细胞沉降率(erythrocyte sedimentation rate,ESR)、C反应蛋白(C-reactive protein,CRP)、免疫球蛋白、血脂等指标,依据甲状腺功能情况进行分组比较。结果:70例DM患者中甲状腺功能异常者达48%,主要表现为甲状腺功能减低,但患者多无甲状腺功能减低的临床症状。与甲状腺功能正常组比较,甲状腺功能异常组的患者多见发热、V型征、Gottron征,也常出现CRP、IgG升高,两组患者系统器官受累情况及肿瘤发生率比较差异无统计学意义。结论:DM患者甲状腺功能异常的发生率高,常表现为亚临床型甲状腺功能减低,可能与两种疾病存在共同的免疫机制有关,临床上应予重视。
Objective：To study the clinical and immunological features of dermatomyositis（DM） complicated with thyroid dysfunction.Methods： Between 1993 and 2008,dermatomyositis was diagnosed in 70 patients referred to the Department of Rheumatology of Peking University People＇s Hospital.Clinical and laboratory data including antibodies,erythrocyte sedimentation rate（ESR）,C-reactive protein（CRP）,immunoglobulin,protein electrophoresis,and serum lipid levels,etc.were retrospectively analyzed.Results： 48% of DM patients had their thyroid function impaired,most of whom suffered from subclinical hypothyroidism.DM patients with thyroid dysfunction were more likely to have higher levels of CRP and IgG as well as higher incidences of fever and erythra.Conclusion： Subclinical thyroid dysfunction with DM is not rare.Common immunological background may be responsible for this phenomenon and it should not be neglected.
出处
《北京大学学报（医学版）》
CAS
CSCD
北大核心
2011年第2期209-212,共4页
Journal of Peking University:Health Sciences
