摘要
虚拟心脏建模是连接心脏宏观和微观研究的有效手段之一。本研究利用微型计算机和可视人断层数据,通过图像增强、组织分割和三维重建,建立了分辨率为0.5 mm×0.5 mm×0.5 mm的心脏结构和胸前表面几何模型;以单细胞动作电位仿真为基础,使用改进的规则型算法,基于惠更斯原理的各向同性和各相异性波面型算法,分别完成了特殊传导系统、心房和心室电活动的仿真,时间精度可达1 ms;结合双域模型理论,使用偶极子等效心脏的电活动,同时结合躯体模型,完成了心脏电活动到体表心电的映射,进行正常和异常情况下体表电位标测图(BSPM)及12导联心电图的仿真。通过此模型得到的由窦房结起搏的体表12导联心电图,满足正常心电的诊断标准,证明了模型的真实性和可靠性,为进一步探讨传导和起搏异常的体表心电建立基础。
Virtual heart modeling is one of effective approaches connecting macroscopic and microscopic studies on cardiac activities,Using visible human dataset and microcomputer,we constructed a geometric heart model with a resolution of 0.5 mm × 0.5 mm × 0.5 mm.Methods involving this procedure included image enhancement,tissue segmentation and three-dimensional reconstructions.Based on cellular action potential simulation,the propagation of electrical activation in heart special conduction system,atrium and ventricle was simulated using different algorithms,including a modified formalized algorithm,the isotropic and anisotropic wavefront propagation algorithms according to Huygens’s principle,with a time accuracy of 1 ms.Meanwhile,the normal and abnormal body surface potential mapping（BSPM） and 12-leads ECG were produced by means of using dipole to represent the cardiac current source,combined with the bidomain model and a thorax model.The results showed that,the simulated surface ECG paced by the sinus mode was consistent with the normal ECG diagnostic standards,which proved the reality and reliability of the model.Our work could provide a basis for further studies on irregular BSPM and ECG such as abnormal conduction and ectopic pacing.
出处
《中国生物医学工程学报》
CAS
CSCD
北大核心
2011年第2期240-249,共10页
Chinese Journal of Biomedical Engineering
基金
国家自然科学基金(81071225)
关键词
全心模型
电生理建模
心肌各向异性
仿真
体表电位标测图(BSPM)
whole heart model
electrophysiological modeling
myocardium anisotropy
simulation
body surface potential mapping
