期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

肝性脑病发病机制研究新进展 被引量：5

原文传递
导出
摘要 肝性脑病（hepatic eneephalopathy，HE）是以严重肝脏疾病和（或）门体分流所致的代谢紊乱为基础的中枢神经系统功能失调综合征，以神经精神症状为主。HE是重症或晚期肝病、某些肝胆疾病术后常见的并发症，是肝脏解毒功能不全和衰竭的表现，其发病机制目前尚未完全阐明，
作者 段志军 张鸣
机构地区 大连医科大学附属第一医院消化内科 西安医学院第二附属医院消化内科
出处 《中华内科杂志》 CAS CSCD 北大核心 2011年第5期441-443,共3页 Chinese Journal of Internal Medicine
基金 基金项目：国家自然科学基金资助项目（30970886） 大连市科技计划基金资助项目（2008E13SF193）
关键词 发病机制 肝性脑病 中枢神经系统功能失调 神经精神症状 肝脏疾病 代谢紊乱 门体分流 晚期肝病
分类号 R747.9 [医药卫生—神经病学与精神病学]
  • 相关文献

参考文献3

二级参考文献26

  • 1杨存社,曹栓余,贺小娟,王永席,张永利.幽门螺旋杆菌感染与肝硬化高氨血症及肝性脑病发病的相关性研究[J].中国危重病急救医学,2007,19(7):422-424. 被引量：15
  • 2Miese F,Kircheis G,Wittsack HJ,Wenserski F,Hemker J,M(o)dder U,et al.1H-MR spectroscopy,magnetization transfer,and diffusion-weighted imaging in alcoholic and nonalcoholic patients with cirrhosis with hepatic encephalopathy.AJNR Am J Neuroradiol 2006; 27:1019-1026.
  • 3Blei AT.The pathophysiology of brain edema in acute liver failure.Neurochem Int 2005; 47:71-77.
  • 4Kato M,Hughes RD,Keays RT,Williams R.Electron microscopic study of brain capillaries in cerebral edema from fulminant hepatic failure.Hepatology 1992; 15:1060-1066.
  • 5Ranjan P,Mishra AM,Kale R,Saraswat VA,Gupta RK.Cytotoxic edema is responsible for raised intracranial pressure in fulminant hepatic failure:in vivo demonstration using diffusion-weighted MRI in human subjects.Metab Brain Dis 2005; 20:181-192.
  • 6Reddy PV,Rama Rao KV,Norenberg MD.Inhibitors of the mitochondrial permeability transition reduce ammoniainduced cell swelling in cultured astrocytes.J Neurosci Res 2009; 87:2677-2685.
  • 7Papadopoulos MC,Verkman AS.Aquaporin-4 and brain edema.Pediatr Nephrol 2007; 22:778-784.
  • 8Verkman AS,Binder DK,Bloch O,Auguste K,Papadopoulos MC.Three distinct roles of aquaporin-4 in brain function revealed by knockout mice.Biochim Biophys Acta 2006; 1758:1085-1093.
  • 9Yang B,Zador Z,Verkman AS.Glial cell aquaporin-4 overexpression in transgenic mice accelerates cytotoxic brain swelling.J Biol Chem 2008; 283:15280-15286.
  • 10Papadopoulos MC,Verkman AS.Aquaporin-4 gene disruption in mice reduces brain swelling and mortality in pneumococcal meningitis.J Biol Chem 2005; 280:13906-13912.

共引文献21

同被引文献40

  • 1邢卉春.肝性脑病诊断治疗专家共识[J].中国肝脏病杂志（电子版）,2009,1(2):46-55. 被引量：40
  • 2贾林,李瑜元.亚临床型肝性脑病[J].中华内科杂志,1996,35(7):495-497. 被引量：49
  • 3Patel D, McPhail MJ, Cobbold JF. Hepatic encephalopathy [J]. Br J Hosp Med (Lond), 2012, 73 (2): 79-85.
  • 4Jadad AR, Moore RA, Carroll D, et al. Assessing the quality of reports of randomized clinical trials: is blinding necessary? [J]. Control ClinTrials, 1996, 17 (1): 1-12.
  • 5Kircheis G, Nilius R, Held C, et al. Therapeutic efficacy of L- omithine - L - aspartate infusions in patients with cirrhosis and hepatic encephalopathy: results of a placebo - controlled, double - blind study [J]. Hepatology, 1997, 25 (6): 1351-1360.
  • 6Stauch S, Kircheis G, Adler G, et al. Oral L - ornithine - L - aspartare therapy of chronic hepatic encephalopathy: results of a placebo - controlled double-blind study [J]. J Hepatol, 1998, 28 (5) : 856 -864.
  • 7Ahmad I, Khan AA, Alam A, et al. L - ornithine - L - aspartate infusion efficacy in hepatic encephalopathy [ J ]. J Coil Physicians Surg Pak, 2008, 18 (11): 684-687.
  • 8Schmid M, Peck - Radosavljevic M, Konig F, et al. A double - blind, randomized, placebo - controlled trial of intravenous L - oraithine- L- aspartate on postural control in patients with cirrhosis [ J ]. Liver Int, 2010, 30 (4): 574-582.
  • 9Abid S, Jafri W, Mumtaz K, et al. Efficacy of L - omithine - L - aspartate as an adjuvant therapy in cirrhotic patients with hepatic encephalopathy [J]. J Coll Physicians Surg Pak, 2011, 21 (11): 666 - 671.
  • 10Mittal VV, Sharma BC, Sharma P, et al. A randomized controlled trial comparing lactulose, probiotics, and L - ornithine - L - aspartate in treatment of minimal hepatic encephalopathy [J]. Eur J Gastroenterol Hepatol, 2011, 23 (8): 725-732.

引证文献5

二级引证文献23

中华内科杂志
2011年 第5期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部