摘要
目的:探讨SPG4型和SPG31型遗传性痉挛性截瘫(HSP)的MRI特征。方法:对经基因确诊的SPG4型和SPG31型2个家系8例HSP患者的MRI图像进行分析,并与16例性别及年龄相匹配的健康对照者MRI图像进行对照研究。采用1.5TMRI扫描仪对24例受试者行颅脑及脊髓MRI检查,分别测量C2、C7、T4、T9椎体水平脊髓横断面积,测量结果进行统计学分析。结果:8例患者颅脑MRI检查均未见明显异常。SPG31型HSP患者C2、C7、T4、T9椎体水平脊髓横断面积分别是(50.13±3.43)mm2、(40.45±2.00)mm2、(22.03±4.55)mm2、(26.10±4.55)mm2,与其对照组间差异有统计学意义(P值均<0.007)。SPG4型HSP患者脊髓横断面积与其对照组间差异无统计学意义。结论:SPG4型和SPG31型HSP患者颅脑MRI表现正常;SPG4型HSP患者脊髓MRI未见异常;SPG31型HSP患者可见颈髓及胸髓萎缩,蛛网膜下腔扩大。
To investigate features of the magnetic resonance imaging in two pedigrees with hereditary spastic paraplegia type 4 and type 31. Methods： Eight HSP patients in two families were determined as SPC,4 or SPG31 by genetic linkage analysis. MRI of brain and the whole spinal cord were performed in these g patients and 16 age and gender matched control subjects utilizing a 1.5T magnet. Cross sectional areas of the spinal cord at the levels of C2, C7, T4, T9 were measured and data was statistically analyzed using the student＇s t test, an association between the spinal cord size and severity of the disease was analyzed using the spearman rank correlation test. Results： All patients had grossly normal MRI of the brain. The cross sectional areas of SPG31 subjects at the levels of C2, C7, T4, T9 were （50.13±3.43）mm2, （40.45±2.00）mm2, （22.03±4.55）mm2, （26.10±4.55）mm2 respectively. All of these values were less than those in the healthy controls（t=6.331, 6.889, 4.647, 3.345 respectively, P〈0.007）. While analysis of the cross-sectional areas in SPG4 subjects had no significant abnormal- ities. There was no association between the degree of spinal cord atrophy and severity and duration of the disease in these two genetic subtypes of HSP. Conclusions： The degree of spinal cord atrophy varies among different genetic types of HSP. Cervical and thoracic MRI of SPG31 subjects revealed atrophies of the spinal cord and enlarged subaraehnoid cavity.
出处
《中国临床医学影像杂志》
CAS
北大核心
2011年第4期254-257,共4页
Journal of China Clinic Medical Imaging
基金
国家科技基础条件平台重点项目中国人类遗传资源的收集与利用子项目(2006DKA21301-1)
山东省自然科学基金资助项目(ZR2009CM094)
关键词
痉挛性截瘫
遗传性
磁共振成像
Spastic paraplegia, hereditary
Magnetic resonance imaging
