摘要
目的探讨脾窦岸细胞血管瘤(LCA)的临床与病理学特征、诊断与鉴别诊断。方法对3例脾窦岸细胞血管瘤进行临床与病理学观察,并复习相关文献。结果患者CT增强扫描提示动脉期及门静脉期脾内有多发性、大小不一的无明显强化低密度影,境界清楚,延迟期病灶部分强化,密度与正常脾组织相似。组织学特点为肿瘤由互相吻合的腔隙组成,部分区域呈乳头状结构,瘤细胞呈柱状或立方形,细胞无明显异型,内皮细胞及组织细胞标记均呈阳性。例2伴有食管小细胞癌。结论脾LCA是一种罕见的脾血管源性肿瘤,其诊断主要依靠病理组织学及免疫组化标记,CT增强扫描可能有助于诊断。由于该肿瘤常伴发内脏恶性肿瘤,对此类患者应进行仔细检查及密切随访。
Purpose To investigate the cliniaopathological features,the main points of diagnosis and differential diagnosis of littoral cell angioma（LCA） in the spleen.Methods Three cases of LCA in the spleen were analyzed with clinical data,histopathology,immunohistochemistry and review of the literature.Results There were multiple nodules in varied size,which were hypo-dense on contrast enhancement CT images on arterial and portal phase,and delayed scans showed further enhancement which was resemble to normal spleen.Two cases of LCA were characterized histologically by anastomosing vascular channels,papillary formation in some area,which were lined by tall or cube cells with no atypia.Immunohistochemical studies showed that the lining cells were positive for endothelial markers and hisriocytic markers.The second case was associated with small cell carcinoma in the oesophgus.Conclusion LCA is a very rare vascular lesion of the spleen,and the diagnosis is depended on the microscopic and immunohiatochemical features.The contrast enhancement CT images may be helpful for establishing the diagnosis.LCA is ofen associated with visceral neoplams,and so close follow-up and investigation is necessary.
出处
《诊断病理学杂志》
CSCD
2011年第2期110-112,共3页
Chinese Journal of Diagnostic Pathology
关键词
脾肿瘤
窦岸细胞血管瘤
免疫组化
诊断
Spleen neoplasms
Littoral cell angioma
Immunohistochemistry
Diagnosis
