期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

CD4^+CD25^+Treg细胞在系统性红斑狼疮中作用机制的研究进展 被引量：2

Advances of research on the role of regulatory T cells in system lupus erythematosus
暂未订购
导出
摘要 系统性红斑狼疮(SLE)是一种多器官损伤的自身免疫性疾病。虽然其发病机制还不完全清楚,但遗传、免疫紊乱、激素水平、环境等多种因素和它的发生有关。调节性T细胞(Treg)作为外周免疫耐受的关键,在SLE中起重要作用。针对Treg在SLE中作用机制的研究已取得了很大进展,但所得结论却存在差异。该文以现有的对Treg的研究结果为出发点,将Treg与该病的关系作一综述。
作者 王维 邓丹琪
机构地区 昆明医学院第二附属医院皮肤性病/风湿免疫科
出处 《临床皮肤科杂志》 CAS CSCD 北大核心 2011年第5期306-309,共4页 Journal of Clinical Dermatology
关键词 调节性T细胞 系统性红斑狼疮 叉头状/翅膀状螺旋转录因子
分类号 R593.24 [医药卫生—内科学]
  • 相关文献

参考文献8

  • 1Zhang B,Zhang X,Tang FL,et al.Clinical significance of increased CD4+CD25-Foxp3+ T cells in patients with new-onset systemic lupus erythematosus[J].Ann Rheum Dis,2008,67(7):1037-1040.
  • 2Bonelli M,Savitskaya A,Steiner CW,et al.Phenotypic and functional analysis of CD4+CD25-Foxp3+T cells in patients with systemic lupus erythematosus[J].J Immunol,2009,182(3):1689-1695.
  • 3Nadkami S,Mauri C,Ehrenstein MR.Anti-TNF-alpha therapy induces a distinct regulatory T cell population in patients with rheumatoid arthritis via TGF-beta[J].J Exp Med,2007,204(1):33-39.
  • 4Bonelli M,von Dalwigk K,Savitskaya A,et al.Foxp3 expression in CD4+T cells of patients with systemic lupus erythematosus:a comparative phenotypic analysis[J].Ann Rheum Dis,2008,67(5):664-671.
  • 5Horwitz DA.Identity of mysterious CD4+CD25-Foxp3+cells in SLE[J].Arthritis Res Ther,2010,12(1):101.
  • 6Tran DQ,Ramsey H,Shevach EM.Induction of FOXP3 expression in naive human CD4+ FOXP3 T cells by T-cell receptor stimulation is transforming growth factor-beta dependent but does not confer a regulatory phenotype[J].Blood,2007,110(8):2983-2990.
  • 7张飚,张烜,唐福林,朱立平,刘音.初发系统性红斑狼疮患者外周血CD4^＋CD25^＋Foxp3^＋和CD4^＋CD25^-Foxp3^＋T细胞[J].中国免疫学杂志,2008,24(9):831-836. 被引量：1
  • 8Vargas-Rojas MI,Crispin JC,Richaud-Patin Y,et al.Quantitative and qualitative normal regulatory T cells are not capable of inducing suppression in SLE patients due to T-cell resistance[J].Lupus,2008,17(4):289-294.

二级参考文献26

  • 1Fattorossi A, Battaglia A et al. Circulating and thymic CD4 CD25 T regulatory cells in myasthenia gravis: effect of immunosuppressive treatment [ J]. Immunology, 2005 ; 116 : 134-141.
  • 2de Kleer I M, Wedderbum L R,Taams L S et al. CD4^+ CD25 bright regulatory T cells actively regulate inflammation in the joints of patients with the remitting form of juvenile idiopathic arthritis[J]. J Immunol, 2004; 172:6435-6443.
  • 3Cao D,van Vollenhoven R, Klareskog L et al. CD25brightCD4^+ regulatory T cells are enriched in inflamed joints of patients with chronic rheumatic disease[J]. Arthritis Res Ther,2004; 6: R335-R346.
  • 4Longhi M S,Ma Y, Bogdanos D P et al. Impairment of CD4( + )CD25 (+) regulatory T-cells in autoimmune liver disease [J]. J Hepatol, 2004;41:31-37.
  • 5Koonpaew S,Shen S,Flowers L et al.LAT-mediated signaling in CD4 %^+ CD25^+ regulatory T cell development [ J ]. J Exp Med, 2006; 203 : 119- 129.
  • 6Valencia X, Yarboro C, lllei G et al. Deficient CD4^+ CD25 high T regulatory cell function in patients with active systemic lupus erythematosus [J]. J Immunol, 2007; 178 : 2579-2588.
  • 7Xue C,Lan-Lan W,Bei C et al.Abnormal Fas/FasL and caspase-3-mediated apoptotic signaling pathways of T lymphocyte subset in patients with systemic lupus erythematosus [ J ]. Cell Immunol, 2006; 239: 121- 128.
  • 8Dejica D. Serum soluble IL-2 receptor as a marker of lymphocyte activation in some autoimmune diseases. Effect of imrnunosuppressive therapy [J]. Roum Arch Microbiol Immunol, 2001 ;60:183-201.
  • 9Chen W,Jin W, Hardegen N et al. Conversion of peripheral CD4^+ CD25- naive T cells to CD4^ + CD25 ^+ regulatory T ceils by TGF-beta induction of transcription factor Foxp3 [ J ]. J Exp Med, 2003 ; 198 : 1875-1886.
  • 10Wang J,Ioan-Facsinay A, van der Voort E I et al. Transient expression of FOXP3 in human activated nonregulatory CD4 ^+ T cells[ J]. Eur J Immunol, 2007 ; 37 : 129-138.

同被引文献11

引证文献2

临床皮肤科杂志
2011年 第5期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部