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志贺菌的致病机制研究进展 被引量：3

Research progress on pathogenic mechanism of Shigellae
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摘要 志贺菌是细菌性痢疾的重要病原体，其致病机制复杂，包括细胞机制和免疫机制等多方面。此文就志贺菌M细胞转位与上皮细胞感染抑制炎症反应、逃逸宿主细胞的吞噬作用及诱导巨噬细胞凋亡方面的研究进展作了综述。 Shigellae is an important pathogen cause of bacillary dysentery. The pathogenic mechanisms of Shigellae are complicated which include cell mechanism and immunologic mechanism and so on. In this paper, the re,arch progress on microfold cell translacation and epithelium cell infecton, controling inflammatory reaction, escaping the host cell and inducing macrophage apoptosis are reviewed.
作者 王国富 白丽
机构地区 大理学院医学微生物学及免疫学教研室
出处 《国际流行病学传染病学杂志》 CAS 2011年第2期137-139,共3页 International Journal of Epidemiology and Infectious Disease
基金 云南省教育厅科学研究基金重点项目（09Z0078）
关键词 志贺菌 致病机制 细菌性痢疾 Shigellae Pathogenic mechanism Bacillary dysentery
分类号 R378 [医药卫生—病原生物学]
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参考文献20

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同被引文献26

  • 1Ramarao N, Le CC, Izard T,et al. Capping of actin filaments by vinculin activated by the Shigella IpaA carboxyl-terminal domain[J]. FEBS Lett, 2007, 581 (5) 853-857.
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  • 6Hamiaux C, Van EA, Parsot C,et al. Structural mimicry for vinculin activation by IpaA, a virulence factor of Shigellaflexneri [J]. EMBO Rep, 2006,7 ( 8 ):794-799.
  • 7Schroeder GN, Hilbi H.Molecular pathogenesis of Shigella spp.: controlling host cell signaling, invasion, and death by type III secretion [J]. Clin Microbiol Rev, 2008, 21 (1): 134-156.
  • 8Sani M, Botteaux A, Parsot C,et al. IpaD is localized at the tip of the Shigellaflexneri type III secretion apparatus [J]. Biochim Biophys Acta, 2007, 1770(2): 307-311.
  • 9Hamiaux C,Van EA,Parsot C,et al.Structural mimicry for vinculin activation by IpaA,a virulence factor of Shigella flexneri.EMBO Rep,2006,7(8):794-799.
  • 10Schroeder GN,Hilbi H.Molecular pathogenesis of Shigella spp.:controlling host cell signaling,invasion,and death by type III secretion[J].Clin Microbiol Rev,2008,21(1):134-156.

引证文献3

二级引证文献15

国际流行病学传染病学杂志
2011年 第2期

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