摘要
目的：探讨口服米非司酮进行药物流产与继后妊娠胚胎停育是否相关。方法：选取2003年5月~2010年5月期间于廓坊市妇幼保健中心门诊手术室行人工流产术或清宫术,年龄为22~35岁,孕7~12周的健康妇女3 233例作为研究对象进行前瞻性研究,其中因胚胎停育而行清宫术者896例作为病例组,自愿要求终止妊娠胚胎无任何异常者2 337例为对照组。结果：病例组中有米非司酮服用史者284例,占31.7%,无米非司酮服用史者612例,占68.3%;对照组中有米非司酮服用史者657例,占28.1%,无米非司酮服用史者1 680例,占71.9%,米非司酮服用史与胚胎停育的发生率具有统计学意义（P〈0.05）。病例组中米非司酮服用时间与此次妊娠间隔不足两年者73例,占25.7%,间隔时间在两年以上者211例,占74.3%;对照组中米非司酮服用时间与此次妊娠间隔不足两年者129例,占19.6%,间隔时间在两年以上者528例,占80.4%,米非司酮的服用与再次妊娠的间隔时间也与胚胎停育的发生率具有统计学意义（P〈0.05）。结论：口服米非司酮会增加继后再次妊娠胚胎停育的风险,尤其是在间隔时间两年之内。
Objective：To explore whether drug induced-abortion by oral administration of mifepristone is related to subsequent missed abortion.Methods：3 233 healthy women aged 22～35 years old of 7～12 gestational weeks who underwent artificial abortion or complete curettage of uterine cavity in the hospital from May 2003 to May 2010 were selected as study objects,then a prospective study was conducted,896 cases receiving complete curettage of uterine cavity because of missed abortion were selected as case group,2 337 cases without any abnormalities who demanded termination of pregnancy voluntarily were selected as control group.Results：In case group,284 cases had the history of taking mifepristone,accounting for 31.7%;612 cases didn＇t have the history of taking mifepristone,accounting for 68.3%.In control group,657 cases had the history of taking mifepristone,accounting for 28.1%;1 680 cases didn＇t have the history of taking mifepristone,accounting for 71.9%.There was significant difference in the incidence of missed abortion between the cases with the history of taking mifepristone and the cases without the history of taking mifepristone（P0.05）.In case group,the interval time between taking time of mifepristone and the subsequent pregnancy of 73 cases was less than 2 years,accounting for 25.7%;the interval time between taking time of mifepristone and the subsequent pregnancy of 211 cases was more than 2 years,accounting for 74.3%.In control group,the interval time between taking time of mifepristone and the subsequent pregnancy of 129 cases was less than 2 years,accounting for 19.6%;the interval time between taking time of mifepristone and the subsequent pregnancy of 528 cases was more than 2 years,accounting for 80.4%.There was significant difference in the incidence of missed abortion between the cases with the interval time between taking time of mifepristone and the subsequent pregnancy less than 2 years and the cases with the interval time between taking time of mifepristone and the subsequent pregnancy more than 2 years（P0.05）.Conclusion：Oral administration of mifepristone can increase the risk of missed abortion during subsequent pregnancy,especially within two years between taking time of mifepristone and the subsequent pregnancy.
出处
《中国妇幼保健》
CAS
北大核心
2011年第13期2006-2007,共2页
Maternal and Child Health Care of China
基金
河北省科学技术研究与发展计划项目〔10276126〕
关键词
米非司酮
药物流产
胚胎停育
Mifepristone
Drug induced-abortion
Missed abortion
