摘要
目的 颅内血管外皮细胞瘤（HPC）,较为罕见,局部复发和远处转移率较高.临床上常需与血管瘤型脑膜瘤、孤立性纤维瘤（SFT）相鉴别,本组采用免疫组化方法来鉴别这三种肿瘤.方法 采用免疫组化方法对1993至2010年收治的11例HPC患者进行回顾性分析,并基于染色结果重新评估临床诊断.结果 根据免疫组化结果,在11例中有1例因CD34和Bcl-2染色阳性被重新诊断为SFT,有1例因EMA强阳性被诊断为血管瘤型脑膜瘤.随访期内,有3例HPC患者复发,1例HPC患者死亡.结论 考虑到SFT和血管瘤型脑膜瘤较HPC预后良好,初步诊断时应严格进行免疫组化检查,对这三种肿瘤的鉴别诊断起着重要作用.
Objective Intracranial hemangiopericytomas （HPCs） were rare neoplasms with relatively high rates of recurrence and extracranial metastasis. The differential diagnoses from angiomatous meningiomas and solitary fibrous tumors（SFTs） are very important. This study is aimed to reveal differences in the specific immunohistochemical features of HPCs, angiomatous meningiomas and SFTs by newly developed immunohistochemical methods. Method Eleven sequential cases of HPC diagnosed in Renji hospital between 1993 and 2010 were retrospectively analyzed by immunohistochemical staining for CD34,Bcl -2 and epithelial membrane antigen （ EMA ）. The cases were then re - evaluated and newly diagnosed based on the results of the immunohistochemical stainings. Results One of the eleven cases was newly diagnosed as SFTs and nine were reconfirmed as HPCs, based on the immunohistochemical studies for CD34,Bcl - 2 and EMA staining. One case was newly diagnosed as angiomatous meningioma on the basis of a strong EMA staining positivity. Three HPCs recurred and one HPC patient died of the tumor. Conclusions Given that SFTs and angiomatous meningioma have a considerably better prognosis than HPCs, it is important to carry out meticulous immunohistochemical examinations for primary diagnosis.
出处
《中华神经外科杂志》
CSCD
北大核心
2011年第3期261-263,共3页
Chinese Journal of Neurosurgery
基金
上海市教育委员会科研创新项目（09YZ81）
上海高校选拔培养优秀青年教师科研专项基金
上海交通大学医学院附属仁济医院优秀青年教师基金
