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以端粒DNA的G四联体为作用靶点的端粒酶抑制剂

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摘要 端粒是真核细胞染色体末端的一种特殊结构,端粒酶的活化是细胞永生化和肿瘤发生所必需的,因此抑制端粒酶活性可能抑制肿瘤的生长和转移。端粒是端粒酶作用的靶位,端粒酶要结合到端粒上才能起作用。端粒部位富含G,G四联体在体外能抑制端粒酶的活性,G四联体就成了新的抗肿瘤药物靶位。几种基于G四联体的端粒酶抑制剂。
作者 张波 潘庆东
出处 《医学信息(中旬刊)》 2011年第5期1994-1995,共2页 Medical Information Operations Sciences Fascicule
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