摘要
目的探讨体外循环(CPB)对循环巨核细胞和血小板的影响及意义。方法观察测定20例患者体外循环(CPB)前后巨核细胞、血小板计数(PLT)值变化,探讨体外循环(CPB)对循环巨核细胞和血小板的影响及意义。结果手术前、中、后中心静脉血的巨核细胞和4-型巨核细胞数量总数量高于同期周围动脉血的细胞总数量。体外循环中中心静脉血巨核细胞和4-型巨核细胞数量比术前和术后均升高,体外循环中血小板数量比术前和术后均降低(P<0.01)。结论体外循环可以导致巨核细胞和血小板数量的改变,循环巨核细胞可能在肺中被破坏、损耗;急性肺损伤可能影响血小板数量。
Objective To explore cardiopulmonary bypass＇ s influence on platelet and megakaryocytes. Methods Megakaryocytes and platelet count （ PLT ） in 20 patients before and after eardiopulmonary bypass （ CPB ） were measured. To explore cardiopulmonary bypass＇ s influence on platelet and megakaryocytes. Results The total number of megakaryocytes and 4-type of megakaryocytes in venous blood were higher than the same arterial blood. The total number of megakaryocytes and 4--type of megakaryocytes in venous blood within CPB were higher than before and after CPB. PLT within CPB were lower than before and after CPB （ P〈0.01 ） . Conclusion CPB can lead to changes of platelet count and megakaryocytes. Platelets and megakaryocytes were destructed in lung by CPB. Injury in acute lung may affect the quantity of platelet.
出处
《中国现代医生》
2011年第15期144-145,151,共3页
China Modern Doctor
基金
浙江省温州市科技计划项目
项目编号:Y20080152
关键词
体外循环
巨核细胞
血小板
Cardiopulmonary bypass
Megakaryocyte
Platelet
