摘要
目的 研究肝细胞癌ＤＮＡ 倍体类型与放射治疗预后的关系。 方法 ４１ 例肝癌患者，其中男性３７例，女性４ 例，用肝瘤穿刺吸取标本并进行ＤＮＡ 倍体类型分析。 结果 ①二倍体肝癌１７ 例（占４１５ ％） ，异倍体肝癌２４ 例（ 占５８５ ％ ） 。②放射治疗过程中，异倍体肝癌恶化者明显较二倍体肝癌为多（Ｐ＜ ００１） ，其预后亦较二倍体肝癌差（ Ｐ＜ ００１）。③不同倍体类型的表现与肿块大小、肿瘤大体类型、ＡＦＰ水平及癌细胞的分化程度并无显著关系。 结论 肝细胞癌的倍体类型有独立的生物学行为，对估计患者预后有积极意义。
To study the relationship between DNA ploidy and prognosis in hepatocellular carcinoma.METHODS 41 Patients were entered into this study,37 of which were male and 4 were female. Specimens obtained by percutaneous liver puncture were analysed by flow cytometry.RESULTS ①17 patients (41.5%) were diploid and the others (58.5%) were aneuploid.②In the course of radiation therapy,patients with aneuploid type were more frequently correlated with progressive disease ( P <0 01) and with poorer prognosis than those with diploid type ( P <0 01) ③No significant difference in DNA ploidy was seen with regard to tumor size,gross type,AFP levels,and histopathologic grade ( P>0 05)。CONCLUSIONS DNA ploidy has its own biological behavior,which has great significance in evaluating the prognosis of patients.
出处
《中国癌症杂志》
CAS
CSCD
1999年第3期203-205,共3页
China Oncology
