摘要
目的:观察拉贝洛尔联合硫酸镁治疗重度妊娠高血压疾病患者降压效果及对其预后的影响。方法:重度妊娠高血压疾病患者75例随机分为3组:单纯用硫酸镁治疗(对照组)25例、拉贝洛尔治疗组25例、拉贝洛尔联合应用硫酸镁组25例。对孕妇进行血压监测,进行胎儿心电图监测,并跟踪记录新生儿分娩情况进行临床分析。结果:拉贝洛尔组和联合用药组在用药1h后收缩压、舒张压较对照组明显下降(P<0.05),拉贝洛尔组用药3h后血压达到理想控制水平,但是联合用药组在用药2h后血压达到目标值。对照组因血压难以控制,提前终止妊娠8例,而在联合用药组仅2例提前终止妊娠,两者有统计学差异(P<0.05),产后出血并发症未见统计学差异(P>0.05),联合用药组新生儿窒息并发症显著低于对照组(P<0.05)。结论:拉贝洛尔与硫酸镁联合用药起效快,降压平稳,安全性高,降低产后并发症。
Objective:To observe the effect of Labetalol combined with Magnesium Sulfate on the prognosis and blood pressure of severe gestational hypertension. Methods:75 severe gestational hypertension patients were divided into three groups, that was,Magnesium Sulfate group (Control),Labetalol group,Labetalol combined with Magnesium Sulfate group. The blood pressure, the fetal electrocardiogram and the clinical condition of newborn were monitored. Results:The systolic blood pressure and diastolic pressure had a significant decrease after one hour in Labetalol group and in Labetalol combined with Magnesium Sulfate group(P<0.05). The blood pressure of Labetalol group achieved an ideal state after three hours,but the Labetalol combined with Magnesium Sulfate group had it after two hours. Eight patients in control group had to terminate pregnancy because the blood pressure was out of control,but only 2 patients in Labetalol combined with Magnesium Sulfate group terminated pregnancy. There was a significant difference in control group and in Labetalol combined with Magnesium Sulfate group (P<0.05), while there was no difference in postpartum hemorrhage(P>0.05). The neonatal asphyxia in Labetalol combined with Magnesium Sulfate group was lower than in control group(P<0.05). Conclusion:The combination of Labetalol and Magnesium Sulfate may lead to the safe reduction of blood pressure and the low postpartum complication for severe gestational hypertension.
出处
《长江大学学报（自然科学版）》
CAS
2011年第3期150-151,154,共3页
Journal of Yangtze University(Natural Science Edition)
关键词
拉贝洛尔
硫酸镁
妊娠高血压疾病
预后
Labetalol
Magnesium Sulfate
Gestational hypertension
Prognosis
