摘要
目的探讨新生儿感染时病情严重程度与心肌酶活性变化的关系。方法将收住NICU患感染性疾病的102例新生儿进行新生儿危重病例评分后分为非危重、危重和极危重3组,于入院后24 h内采集静脉血检测谷草转氨酶(AST)、谷丙转氨酶(ALT)、乳酸脱氢酶(LDH)、肌酸激酶(CK)活性及肌酸激酶新型同工酶(CKMB)活性,而后进行各组间比较分析。结果危重组、极危重组患儿心肌酶活性较非危重组明显升高且差异有统计学意义(P<0.01)。结论新生儿感染时危重度分级与心肌酶活性的改变密切相关,血清心肌酶对临床判断新生儿感染性疾病的心肌损害及病情严重程度有一定价值。
Objective To evaluate the relationship between the severity of neonatal infection and the activity change of cardiac enzyme.Methods A total of 102 infectious neonates in NICU were evaluated with neonatal serious illness scoring system and then divided into non-critical,critical,and extremely-critical groups.The activity of such serum myocardial enzymes as AST,ALT,LDH,CK,and CKMB was tested in the first 24 hours on admission.Comparison between groups and analyses were conducted.ResultesMyocardial enzyme of the critical and extremely-critical groups was obviously higher than that of the non-critical group（P0.01）.Conclusion The serious illness score of infectious neonates is closely associated with the activity change of myocardial enzyme and the level of serum myocardial enzymes has certain advantages in judging the myocardial injury and the disease severity of neonatal infection.
出处
《中国循证医学杂志》
CSCD
2011年第5期515-517,共3页
Chinese Journal of Evidence-based Medicine
关键词
新生儿
感染
危重度分级
心肌酶
Neonate
Infection
Critical illness scoring
Myocardial enzyme
