摘要
According to their action on the cell-cycle,cell-cycle, regulatory proteins can be dividedinto two groups: positive and negative cell-cycle regulatory poroeins.Positive group includes cyclin,cyclin-de-pendent kinase(CDK), and downstream targets such as retinoblastoma protein (pRb) and so on. The proteins in-volved in the negative group are named cyclin-kinase inhibitors(CKI) as a whole, consisting of CIP/KIP familyand INK4 family.Cyclins associate with CDKs to form a variety of active complexes, which in trm leads to thephosphorylation of pRb ane other downstream proteins,and this realizes the positive regulatory action.CKI playsa negative regulatory role by inhibiting the activity of cyllin- CDK. By interplaying each other, the two regulatorygroups control the intiation phase transitions,exit and termination of the cell-cycle.
According to their action on the cell-cycle,cell-cycle, regulatory proteins can be dividedinto two groups: positive and negative cell-cycle regulatory poroeins.Positive group includes cyclin,cyclin-de-pendent kinase(CDK), and downstream targets such as retinoblastoma protein (pRb) and so on. The proteins in-volved in the negative group are named cyclin-kinase inhibitors(CKI) as a whole, consisting of CIP/KIP familyand INK4 family.Cyclins associate with CDKs to form a variety of active complexes, which in trm leads to thephosphorylation of pRb ane other downstream proteins,and this realizes the positive regulatory action.CKI playsa negative regulatory role by inhibiting the activity of cyllin- CDK. By interplaying each other, the two regulatorygroups control the intiation phase transitions,exit and termination of the cell-cycle.
出处
《中国病理生理杂志》
CAS
CSCD
北大核心
1999年第10期956-958,共3页
Chinese Journal of Pathophysiology
