摘要
目的：探讨自发性高血压大鼠（SHR）在孕期服转换酶抑制剂卡托普利预防子鼠高血压的作用及其肾素血管紧张素系统机制。方法：观察孕期服卡托普利（Cap100mg·kg-1·d-1）对子鼠收缩压的影响；以放免法和反转录一聚合酶链式反应法分别测血浆、组织血管紧张素Ⅱ（AngⅡ）浓度和组织AngⅡ－Ⅰ型受体（AT1）mRNA表达。结果：红血单纯在孕期服用卡托普利能有效桔抗子鼠随增龄的升压幅度（P＜0.01）；同时降低其大脑皮质、肾皮质地AngⅡ浓度，增高AT1mRNA表达。结论：证实胚胎期是SHR发病的关键阶段，在此期干扰AngⅡ的生成能有效预防子鼠发生高血压，为高血压病的防治提供了实验性启示。
To explore the prevention effect of hypertension and its renin-angiotensin systemmechanism in descendants of SHRs (spontaneously hypertensive rate) by 100mg/kg. d-1 captopril, angiotensin convertingenzyme dribitor, intervention during pregnancy, the systolic blood pressure, plasma and tissue angiotensin(Ang Ⅱ), de-tected by radio-immunoassay, and tissue Ang Ⅱ- Ⅰ type receptor(AT1 ) mRNA expression by reverse transcription-polymerasechain reaction method. RESULTS: Captoprptoil intervention during pregnancy can effectively prevent the increment of bloodpressure by age (P < 0.01 ) in descendant SHRs; and decrease its Ang Ⅱ concentrations in cerebral cortex, while AT1 mR-NA expression incrased. CONCLUSIONS: It is confirmed that the embryo stage might be the critical period for the devel-opment of hypertension in SHR, and the interference of Ang Ⅱ production could effectively prevent the occurrence of hyper-tension in descendant SHRs thus offering an experimental clue for the prevenhon and control of essential hypertension.
出处
《中国病理生理杂志》
CAS
CSCD
北大核心
1999年第10期888-890,共3页
Chinese Journal of Pathophysiology
关键词
高血压
大鼠
卡托普利
妊娠合并症
Hypertension
Rats
Captopril
Angiotensin Ⅱ
Receptors, angiotensin
