摘要
目的观察比索洛尔联合坎地沙坦治疗慢性充血性心力衰竭的疗效。方法 68例慢性充血性心力衰竭患者随机分为治疗组和对照组。在常规治疗的基础上,对照组口服坎地沙坦,治疗组口服坎地沙坦和比索洛尔,治疗24周后观察心功能情况及左室射血分数、心率、6min步行距离和N端B型脑钠肽前体(NT-proBNP)水平。结果治疗组的心功能改善明显优于对照组(P<0.05);两组治疗后的左室射血分数、心率、6min步行距离、NT-proBNP水平差异有统计学意义(P<0.01)。结论比索洛尔联合坎地沙坦治疗慢性充血性心力衰竭可取得较好疗效。
Objective To observe the clinical efficacy of bisoprolol plus candesartan in the treatment of chronic congestive heart failure（CCHF）.Methods Sixty-eight patients with CCHF were randomly divided into treatment and control groups.Based on the conventional therapy,control group received oral candesartan,while treatment group accepted candesartan and bisoprolol.The heart function,left ventricular ejection fraction（LVEF）,heart rate,6-minute walking distance and N-terminal pro-B-type natriuretic peptide（NT-proBNP） level were detected after 24-week treatment.Results The improvement of heart function in treatment group was superior to that in control group（P0.05）.There were significant differences in LVEF,heart rate,6-minute walking distance and NT-proBNP content between both groups（P0.01）.Conclusion The combination of bisoprolol and candesartan can achieve the satisfactory efficacy in CCHF.
出处
《广东医学院学报》
2011年第2期132-134,共3页
Journal of Guangdong Medical College
