摘要
目的：探讨成人Still病（AOSD）患者骨髓象的特点及其与败血症的异同点。方法：回顾性分析了8例AOSD患者的骨髓象并与5例败血症患者进行了比较。结果：（1）AOSD患者颗粒缺乏粒细胞比例显著多于败血症患者（10．8％±5.9％比1．6％±0．9％，P＜0．01）；（2）AOSD患者核浆发育不平衡粒细胞显著多于败血症患者（7．8％±2.7％比3．2％±1.5％，P＜0．05）；（3）AOSD患者巨幼变粒细胞比例显著多于败血症患者（4．7％±2．5％比1．2％±0．8％，p＜0．05）；（4）AOSD患者核分叶过多粒细胞未见，败血症患者易见（3．8％±1．9％）；（5）AOSD患者巨核细胞数量较败血症患者减少且易见病态巨核细胞。结论：AOSD患者骨髓粒细胞系和巨核细胞系存在病态造血现象，骨髓象可为AOSD患者与败血症的鉴别诊断提供线索。
objective: To compare the myelographic features between adult onset Still's disease (AOSD) and septicemia.Methods: The myelograms of 8 cases with AOSD were analysed retrospectively and compared with those of 5 cases with septicemia. Results: (1) The ratio of hypogranular neutrophils in AOSD was significantly greater than in septicemia (10. 8 % ± 5.9 % vs 1. 6 % ± 0. 9 %, p <0. 01); (2)the ratio of neutrophilic myelocytes with imbalance in the development of karyoplasm was significantly greater than in septicemia (7. 8 % ± 2. 7 % vs 3. 2 % ±1. 5 %, p < 0. 05); (3)the ratio of megalo-granularcytes was significantly greater than in septicemia (4. 7 % ± 2. 5 % vs 1. 2 % ± 0. 8 %, p < 0. 05); (4)the hypersegemented neutrophil could not be found in AOSD, but it could be easily found in septicemia (3. 8 %± 1. 9 % ); (5) the amount of megakaryocytes in AOSD was less than that in septicemia and the pathologic mngakaryocytes in AOSD could be easily found in AOSD. Conclusion: The pathologic hematopoiesis in the granulocytic series and the megakaryocytic series existed in AOSD,the myelogram could provide some traces for the differential diagnosis of AOSD and septicemia.
出处
《中国临床医学》
1999年第3期241-242,共2页
Chinese Journal of Clinical Medicine
关键词
成人
STILL病
败血症
骨髓象
Adult onset Still's disease Septicemia Myelogram
