摘要
目的比较TE与TEC方案在乳腺癌新辅助化疗中的近期疗效及毒副反应。方法 63例Ⅱ～Ⅲ期乳腺癌患者随机分为两组,分别接受TE(多西他赛联合表柔比星)和TEC(多西他赛联合表柔比星及环磷酰胺)方案化疗,21 d为1周期,观察化疗后病理反应并评价两组的近期疗效和毒副反应。结果 TE组与TEC组有效率分别为84.4%(27/32)、87.1%(27/31),两者无显著差异。TEC组Ⅱ～Ⅳ度白细胞减少发生率、粒细胞缺乏性发热发生率均较TE组高。结论 TE与TEC方案在乳腺癌新辅助化疗中的疗效相似,TE方案骨髓抑制较TEC方案轻,值得临床上广泛推广应用。
Objective To compare and analyze the effect and side effect of two neoadjuvant chemotherapy regimens（TE and TEC）.Methods The data of 63 female patients with StageⅡand Ⅲa breast cancer was retrospectively analyzed.All patients were received neoadjuvant chemotherapy with TE or TEC regimen before operation.Results Among all the 63 patients,32 patients with breast cancer received TE regimen before operation,the rate of RR was 84.4%（27/32）.31 patients received TEC regimen,the rate of RR was 87.1%（27/31）.In the differences of the clinical response rate between TE and TEC regimen,there were no significant differences.The side effect of TEC was more seriously,which mainly conclude leucopenia and alopecia.Conclusion The effect of the two neoadjuvant chemotherapy regimens（TE and TEC） are similar.The bone marrow suppression of TE regimen is less seriously.It is recommended to utilized widespreadly in clinic.
出处
《安徽医学》
2011年第4期449-451,共3页
Anhui Medical Journal
关键词
乳腺癌
新辅助化疗
毒副反应
Breast cancer
Neoadjuvant chemotherapy
Side effect
