摘要
探讨了燕麦β-葡聚糖对STZ致Ⅱ型糖尿病小鼠胰岛素抵抗的影响.100只雄性昆明种小鼠(20±2)g/只随机分成2组:正常对照组与模型组.造模成功的小鼠随机分成模型对照组、高剂量组、中剂量组、低剂量组、盐酸二甲双胍组5组,每组15只;进行为期6周的试验,测定小鼠血清胰岛素含量,计算胰岛素敏感性指数,测定肝糖原和肌糖原含量,结果表明:不同剂量的燕麦β-葡聚糖均可显著降低小鼠的空腹血糖,刺激胰岛素分泌,改善胰岛素抵抗,提高糖耐量,促进肝、肌糖原合成,其中以2 000 mg/kg.bw的高剂量组效果最佳.
To investigate the effects of oat β-glucan on type Ⅱ diabetic mice caused by STZ, 100 male Kunming mouse （20 ＋ 2） g were divided into two groups：normal control group and model group. Diabetic mice were divided into 5 groups （ each group, n = 15 ） ： model control group, high dose β-glucan group, median dose β-glucan group ,low dose β-glucan group, Metformin hydrochloride Tablets group,which were fed different diets for 6 weeks. Oral glucose tolerance test was carried out six weeks later, serum insulin concentions ,liver glycogen and muscle glycogen were measured,insulin activity indexs were calculated at the end of the experiments. The results showed that the groups of different doses of β-glucan significantly lowered fasting blood glucose. Oat β-glucan could significantly stimulate insulin secretion, improve insulin resistance and glucose tolerance ability,promote synthesis of liver and muscle glycogen. The best was the group high dose β- glucan group（2 000 mg/kg. bw）among all of the oat β-glucan groups.
出处
《郑州轻工业学院学报（自然科学版）》
CAS
2011年第2期5-8,共4页
Journal of Zhengzhou University of Light Industry:Natural Science
基金
国家农业部燕麦产业技术体系建设专项经费资助项目(nyxytx-14)
