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颞叶癫大鼠海马齿状回NT-3表达与突触密度变化的相关性研究 被引量：1

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摘要 目的:探讨神经营养因子-3(NT-3)在颞叶癫大鼠海马齿状回突触重建中的调控作用。方法:采用红藻氨酸(KA)侧脑室内微量注射制作颞叶癫大鼠模型,用免疫组化法检测不同时间点(对照组及致后6,24,48 h,7 d组)大鼠海马齿状回NT-3蛋白的表达,用免疫电镜法在相同时间内检测大鼠海马齿状回突触密度的变化。结果:KA致后6 h,NT-3蛋白在海马齿状回表达开始减少(P<0.01),48 h降至最低,7 d上升;KA致后24 h,海马齿状回突触密度开始减少(P<0.05),48 h最低,7 d上升至正常;NT-3的表达量与突触密度变化呈中度正相关(r=0.536,P<0.05)。结论:NT-3可能对颞叶癫大鼠海马齿状回突触的重建有调控作用,影响其兴奋性。
作者 江天丽 郑金瓯 余璐 邓晓清 陈子蓉
机构地区 广西医科大学第一附属医院神经内科
出处 《广西医科大学学报》 CAS 2011年第1期42-44,共3页 Journal of Guangxi Medical University
基金 广西科学基金资助项目(No.桂科自0640118)
关键词 颞叶癫（疒间） 齿状回 神经营养因子-3 突触密度 大鼠
分类号 R742.1 [医药卫生—神经病学与精神病学]
  • 相关文献

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共引文献10

同被引文献19

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广西医科大学学报
2011年 第1期

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