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四组分一锅法合成三苯胺-吡啶衍生物 被引量：2

Four-component one-pot synthesis of triphenylamine-pyridine derivatives
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摘要 以三苯胺醛、苯乙酮、3-氰基乙酰基吲哚和醋酸铵为原料,分别在传统加热回流和微波辐射条件下,利用四组分一锅法反应,简便地合成了一系列的三苯胺-吡啶衍生物。该方法具有产率较高、操作简单等优点。产物的结构通过了1H NMR,IR和E.A.表征。 A series of triphenylamine-pyridine derivatives were synthesized by four-component one-pot reaction of triphenylamine aldehyde, aeetophenone, 3-eyanoacetyl indole and ammonium acetate at refluxing temperature and microwave irradiation. This method has the advantages of good yield and easy operation. The structures of the products were characterized by 1 H NMR spectra, IR and elemental analysis.
作者 张欣 刘霞 冯国良 张红利 耿丽君
机构地区 河北科技大学理学院
出处 《河北工业科技》 CAS 2011年第3期142-145,152,共5页 Hebei Journal of Industrial Science and Technology
关键词 多组分反应 吡啶衍生物 三苯胺醛 3-氰基乙酰基吲哚 微波辐射 multieomponent reaction pyridine derivatives triphenylamine aldehyde 3-cyanoacetyl indole microwave irradiation
分类号 O621.3 [理学—有机化学]
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参考文献16

  • 1NEFZI A,OSTRESH J M, HOUGHTEN R A. The current status of heterocyclic combinatorial libraries[J]. Chem Rev, 1997,97(2) :449-472.
  • 2THOMPSON L A. Recent applications of polymer-supported reagents and scavengers in combinatorial, parallel,or multistep synthesis[J]. Curr Opin Chem Bioi,2000,4(3) :324-337.
  • 3LI M,YANG W L,WEN L R,et al. A first resource-efficient and highly flexible procedure for a four-component synthesis of dispiropyrrolidines[J]. Eur J Org Chem, 2008,16 : 2 751-2 758.
  • 4KUMAR S,SHARMA P,KAPOOR K K,et al. An efficient, catalyst- and solvent-free, four-component, and one-pot synthesis of polyhydroquinolines on grinding[J]. Tetrahedron, 2008, 64(3) : 536-542.
  • 5BAGLEY M C,CALE J W,BOWER J. A new one-pot three-component condensation reaction for the synthesis of 2,3,4,6-tetrasubstituted pyridines[J]. Chem Commun, 2002,16,1 682- 1 693.
  • 6DALLINGER D,GOROBETS N,KAPPE C O. High-throughput synthesis of N3-acylated dihydropyrimidines combining microwave-assisted synthesis and scavenging techniques[J]. Org Lett,2003,5(8):1 205-1 208.
  • 7SMITH A L, STEVENSON G I,LEWlS S, et al. Solid-phase synthesis of 2, 3-disubstituted indoles: Discovery of a novel, high-affinity, selective hS-HT2A antagonist bioorg[J]. Med Chem Lett,2000,24(10) :2 693-2 696.
  • 8LIU Y B, GRIBBLE G W. Bis-suzuki reactions of 2,3-dihaloindoles: A convenient synthesis of 2, 3- diarylindoles[J]. Tetrahedron Lett,2000,41:8 717-8 721.
  • 9THURKAUF A,YUAN J,CHEN X,et al. 2-phenyl-4(5)-[4- (pyrimidin-2-yl) piperazin -1-yl] methylimidazole, A highly selective antagonist at cloned human D4 receptors[J]. J Med Chem,1997,40(1) :1-3.
  • 10ZHANG H C, YE H, MORETTO A F, et al. Facile solid-phase construction of indole derivatives based on a traeeless: Activating sulfonyl linker[J]. Org Lett,2000,2(1):89-92.

同被引文献34

  • 1牛效迪,傅强,潘亚茹,李银燕,郝向荣,赵宝中.酞菁钴吡啶轴向配合物的合成及表征[J].分子科学学报,2005,21(3):25-28. 被引量：8
  • 2田艳青,李文怀.铬酐氧化连续生产吡啶甲酸铬新工艺[J].化学工程师,2005,19(9):53-54. 被引量：5
  • 3钮倩倩,潘利华,李珍,马世盐,谢文兵,林敏,付强.2,6-二溴-4-氨基吡啶的合成[J].分子科学学报,2006,22(6):401-404. 被引量：4
  • 4王毅群,姚明辉.三价铬治疗糖尿病的作用及其机制[J].中国临床药学杂志,2007,16(2):130-132. 被引量：7
  • 5李克昌,曹学静,张恒彬,张玉敏,刘茵,张伟.重铬酸钾氧化法合成2-吡啶甲酸的研究[J].分子科学学报,2007,23(2):82-86. 被引量：6
  • 6JIA Run-hong,YAN Shu,JIANG Bo,et al.Extension of a cascade reaction:Microwave-assisted synthesis of the GFP chromophore deriv-ativesJournal of Heterocyclic Chemistry,2007.
  • 7COX R J,O’’HAGAN D.Synthesis of isotopically labeled 3-amino-2-phenylpropionic acid and its role as a precursor in the biosynthesisof tenellin and tropic acidJournal of the Chemical Society,1991.
  • 8BECKMAN R K,POTENZA J C,ENHOLM E J.Synthetic studies directed toward naturally occurring tetramic acids:Synthesis of(-)-methylydiginate and the tetramic acid subunit for streptolydiginJournal of Organic Chemistry,1987.
  • 9DRAGOVICH P S,PRINS T J,ZHOU R,et al.Structure-based design,synthesis,and biological evaluation of irreversible human rhi-novirus 3Cprotease inhibitors:Structure-activity studies of orally bioavailable,2-pyridone-containing peptidomimeticsJournal of Medicinal Chemistry,2002.
  • 10PARLOW J J,KURUMBAIL R G,STEGEMAN R A,et al.Design,synthesis,and crystal structure of selective 2-pyridone tissue fac-tor VIIa inhibitorsJournal of Medicinal Chemistry,2003.

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河北工业科技
2011年 第3期

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