摘要
人类白细胞抗原（HLA）是参与机体免疫反应的重要分子，参与机体的抗原提呈，决定免疫细胞对肿瘤的识别杀伤。肺癌患者HLA分子表达异常是常见的肿瘤生物学现象，被认为是肿瘤免疫逃逸的重要原因。研究发现，不同类型的肺癌HLA分子表达的情况各不相同，同一型肺癌的不同阶段HLA分子的表达也有差异，HLA分子的表达异常与肺癌的类型、进展、预后都有密切的关系。深入研究HLA分子表达异常与肺癌的关系，以及HLA异常发生机制，对肺癌发生机制的研究和肿瘤免疫治疗提供重要的帮助。
HLA （human leukocyte antigen） is critical molecule relevant to immunoresponse, which is always involved in antigen presentation and determining killing activity of immune cells against tumor. The abnormal expression of HLA in lung cancer is believed to be a common phenomena of tumor biology. It has been demonstrated that HLA expression varies in various types of lung cancer, even in differential stages of one type of lung cancer. HLA expression is highly associated with genre, progression and prognosis of lung cancer. The thorough investigations of the relationship between HLA and lung cancer and of mechanism of HLA abnormality will provide useful information for studying of development of lung cancer and tumor immunotherapy.
出处
《国际肿瘤学杂志》
CAS
2011年第5期370-373,共4页
Journal of International Oncology
