摘要
目的分析癫痫患者卡马西平的血药浓度监测结果,为卡马西平的合理用药提供依据。方法采用高效液相色谱法测定癫痫患者卡马西平血药浓度,并观察患者的临床症状、合并用药的情况。结果 151例次患者中,卡马西平血药浓度低于4μg.mL-1占23.18%,4～12μg.mL-1的占74.17%,,血药浓度大于12μg.mL-1占2.65%。其中出现中毒反应的占12.58%。结论对长期使用卡马西平的患者进行血药浓度监测,可为临床医生制定个体化给药方案提供客观依据,对提高癫痫治疗的安全性、有效性有重要意义。
OBJECTIVE To analyze the monitoring result of serum concentration of carbamazepine in patients with epilepsy and provide evidence for rational use of this drug.METHODS HPLC was used to measure the serum concentration of carbarnazepine.At the same time,the clinical efficacy of these 151 epileptic patients and the situation of drug combination were obsenved.RESULTS The serum concentration of carbamazepine is lower than 4μg·mL-1,4～12μg·mL-1 and higher than 12μg·mL-1 accounted for 23.18%,74.17% and 2.65%.And toxic reaction was accounted for 12.58%.CONCLUSION Monitoring of serum concentration of carbamazepine for long term usage patients provide objective evidence for clinician to make individualized therapeutic regimen and play an important role in raising the safety and effectiveness in the treatment of epilepsy.
出处
《海峡药学》
2011年第5期248-250,共3页
Strait Pharmaceutical Journal
关键词
癫痫
卡马西平
血药浓度监测
个体化给药
Epilepsy
Carbamazepine
Monitoring of serum concentration
Individualized medici
