摘要
目的:探讨糖尿病肾病(DN)患者尿转化生长因子β1(TGF-β1)、α1微球蛋白(α1-MG)及视黄醇结合蛋白(RBP)水平的变化。方法:根据尿白蛋白排泄率(UAER)将65例2型糖尿病患者分成3组,测定尿TGF-β1、α1-MG、RBP含量,并与对照组23名健康体检者进行比较。结果:DN患者尿TGF-β1、α1-MG、RBP水平均高于健康对照组(P<0.05或0.01)。尿TGF-β1、α1-MG、RBP与UAER呈正相关(r分别为0.73,0.62,0.85,P均<0.01)。结论:早期DN患者尿TGF-β1、α1-MG水平升高,可能在评价DN病情进展及预后转归方面有一定临床价值。
Objective：To study the alteration of urinary transforming growth factor（TGF）-β1,α1-microglobulin（MG） and retinol binding proteince（RBP） in patients with diabetic nephropathy（DN）.Methods： TGF-β1,α1-MG and RBP level in urine were measured in 65 cases of type 2 diabetic patients which were divided into 3 groups according to urinary albumin excretion rate（UAER） and compared with 23 cases of healthy adults.Results： The levels of urinary TGF-β1,α1-MG and RBP of patients with DN were higher than those of the control group.A positive correlation was found between urinary TGF-β1,α1-MG,RBP and UAER（r=0.73,0.62,0.85,P0.01）.Conclusions： Urinary TGF-β1,α1-MG and RBP are valuable for the incipient diagnosis of DN and related to the severity of nephropathy and survival of diabetic patients.
出处
《新医学》
2011年第4期244-245,275,共3页
Journal of New Medicine
关键词
糖尿病肾病
尿转化生长因子β1
尿Α1微球蛋白
尿视黄醇结合蛋白
Diabetic nephropathy
Urinary transforming growth factor-β1
Urinary α1-microglobulin
Urinary retinol binding protein
