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原发性高血压与脂联素、C反应蛋白关系及机制的研究进展 被引量：5

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摘要 近年的研究证实,原发性高血压（EH）患者存在血管壁炎性反应,炎性反应可能参与了高血压的发生发展。脂联素具有抗炎及抗动脉硬化作用[1,2]。C反应蛋白（CRP）是参与动脉粥样硬化形成的重要炎性因子[3],目前国内外学者开始探讨EH与脂联素、CRP之间的关系,其可能成为治疗EH的新靶点。本文对近年来EH与脂联素、CRP关系及可能机制作一综述。
作者 闫胜敏 李拥军
机构地区 河北省保定市第一医院心内科 河北医科大学附属第二医院
出处 《临床合理用药杂志》 2011年第7期145-146,共2页 Chinese Journal of Clinical Rational Drug Use
关键词 原发性高血压 脂联素 C反应蛋白
分类号 R544.1 [医药卫生—心血管疾病]
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参考文献34

  • 1Ouchi N,Kihara S,Arita Y,et al.Novel modulator for endothelial adhesion molecules:adipocyte-derived plasma protein adiponectin[J].Circulation,1999,100:2473-2476.
  • 2Ouchi N,Kiham S,Arita Y,et al.Adipocyte derived plasma protein,adiponectin suppresses lipid accumulation and class A scavenger receptor expression in human monocyte-derived macrophages[J].Circulation,2001,103:1057-1063.
  • 3廖裔学,阮海林.急性脑梗死患者C-反应蛋白水平与预后的关系[J].中国医药,2007,2(1):18-20. 被引量：22
  • 4李小平,杨成悌,张灵,常鹏.高血压病患者血清脂联素水平的研究[J].中华心血管病杂志,2004,32(7):596-599. 被引量：37
  • 5毋淑珍,赵洛沙,杨文,薛国华,张静华.原发性高血压患者血清脂联素水平分析[J].河南医学研究,2007,16(2):145-147. 被引量：1
  • 6Iwashima Y,Katsuya T,Ishikawa K,et al.Hypoadiponectinemia is an independent risk factor for hypertension[J].Hypertension,2004,43(6):1318-1323.
  • 7Trimarco B,Volpe M,Ricciardelli B,et al.Studies of the mechanisms underling impairment of beta-adrenoceptor mediated effects in human hypertension[J].Hypertension,1983,5(4):584-590.
  • 8Fasshauer M,Klein J,Neumann S,et al.Adiponectin gene expression is inhibited by β2 adrenergic stimulation via protein kinase A in 3T3-L1 adipocytes[J].FEBS Lett,2001,507(2):142-146.
  • 9Jones BH,Standridge MK,Taylor JW,et al.Angiotensinogen gene expression in adipose tissue:analysis of obese models and hormonal and nutritional control[J].Am J Physiol,1997,273(5):236-242.
  • 10Massiera F,Bloch-Faure M,Ceiler D,et al.Adipose angiotensinogen is involved in adipose tissue growth and blood pressure regulation[J].FASEB J,2001,15(14):2727-2729.

二级参考文献86

  • 1Hopkins PN,Williams RR. A survey of 246 suggested coronary risk factors[J]. Atherosclerosis, 1981,40:1-52.
  • 2EUROASPIRE:a Europan Society of Cardiology survery of secondary prevention of coronary heart disease: principal results[J]. Eur Heart J, 1997,18:1569-1582.
  • 3Ross R. Atheroslerosis-an inflammatory disease[J]. N Engl J Med, 1999,340:115-126.
  • 4Zwaka TP, Hombach V, Torzewski J. C-reactive protein-mediated low density lipoprotein uptake by macrophages:implications for atherosclerosis [ J]. Circulation, 2001,103 :1194-1197.
  • 5Nakagomi A, Freedman SB, Geczy CL. Interferon-gamma and lipopolysaccharide potentiate monocyte tissue factor induction by C-reactive protein: relationship with age, sex,and hormone replacement treatment [J]. Circulation, 2000,101:1785-1791.
  • 6Penn MS, Topol EJ. Tissue factor, the emerging link between inflammation, thrombosis, and vascular remodeling[J]. Cir Res, 2001,89:1-2.
  • 7Yasojima K,Schwab C, McGeer EG, et al. Generation of C-Reactive protein and complement components in atheroscle-rotic plaques[J]. Am J Pathol,2001,158 : 1039-1051.
  • 8Tomai F,Crea F,Gaspardone A, et al. Unstable angina and elevated C-reactive protein levels predict enhanced vasore-activity of the culprit lesion [J]. Circulation, 2001, 104 :1471-1476.
  • 9Pasceri V, Willerson JT, Yeh ET. Direct proinflammatory effect of C-reactive protein on human endothelial cells[J].Circulation, 2000,102 : 2165-2168.
  • 10Nakajima T,Schulte S,Warrington K J, et al. T-cell-media-ted lysis of endothelial cells in acute coronary syndromes[J]. Circulation, 2002,105:570-575.

共引文献393

同被引文献87

  • 1周自强,胡大一,陈捷,张仁汉,李奎宝,赵秀丽.中国心房颤动现状的流行病学研究[J].中华内科杂志,2004,43(7):491-494. 被引量：1408
  • 2Kim SR,Bae YH,Bae SK,et al.Visfatin enhances ICAM-1 and VCAM1 expression through ROS-dependent NF-kappa B activation in endothelial cells[J].Biochim Biophys Acta,2008,1783(5):886-895.
  • 3Adya R,Tan BK,Punn A,et al.Visfatin induces human endothelial VEGF and MMP-2/9 production via MAPK and P13K/Akt signalling pathways:novel insights into visfatin-induced angiogenesis[J].Cardiovasc Res,2008,78(2):356-365.
  • 4Lim SY,Davidson SM,Paramanathan A J,et al.The novel adipocytokine visfatin exerts direct cardioprotective effects[J].J Cell Mol Med,2008, 12(4):1395-1403.
  • 5Chung MK,Martin DO,Sprecher D,et al.C-reactive protein elevation in patients with atrial arrhythmias:inflammatory mechanisms and persistence of atrial fibrillation[J].Circulation,2001,104(24):2886-2891.
  • 6Acevedo M,Cobalan RL,Perez L,et al.C-reactive protein in atrial fibrillation: evidence for the presence of inflammation in the genesis and perpetuation of the arrhythmia[J].J Am Coil Cardiol,2003,41(1):1089- 1091.
  • 7Swynghedauw B.Molecular mechanisms of myocardial remodeling[J]. Physiol Rev,1999,79(10):215-262.
  • 8Shimano M,Shibata R,Tsuji Y,et al.Circulating adiponectin levels in patients with atrial fibrillation[J].Circ J,2008,72(7):1120-1124.
  • 9Anders H,Terry P,Philip E.ACRP30/adiponectin:an adipokine regulating glucose and lipid metabolism[J].Trends Endoerinol Metab, 2002,13(2):84-89.
  • 10Von Eynatten M,Hamann A,Twardella D,et al.Relationship of adiponectin with markers of systemic inflammation,atherogenic dyslipidemia and heart failure in patients with coronary heart disease[J].Clinical Chemistry, 2006,52(5):853-859.

引证文献5

二级引证文献13

临床合理用药杂志
2011年 第7期

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