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Ghrelin在摄食及脂质代谢中的调节作用 被引量：1

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摘要 参与能量代谢调节的因子和激素有很多种,但Ghrelin是目前已知的、唯一的外源性促摄食的脑肠肽,对该方面的相关研究很多,其对机体的葡萄糖代谢,脂质代谢等均有影响。本文就Ghrelin对摄食及脂质代谢方面的影响作一综述。
作者 顾辨辨 严光
机构地区 安徽医科大学附属省立医院安徽省立医院老年医学科
出处 《中国临床保健杂志》 CAS 2011年第2期222-224,共3页 Chinese Journal of Clinical Healthcare
关键词 GHRELIN 脂质代谢 代谢调节 摄食 葡萄糖代谢 脑肠肽 外源性
分类号 R333 [医药卫生—人体生理学]
  • 相关文献

参考文献27

  • 1Wren AM,Small CJ,Ward HL,et al.The novel hypothalamic peptide Ghrelin stimulates food intake and growth hormone secretion[J].Endocrinology,2000,141(11):4325-4328.
  • 2Yamamoto K,Takiguchi S,Miyata H,et al.Randomized phase II study of clinical effects of Ghrelin after esophagectomy with gastric tube reconstruction[J].Surgery,2010,148(1):31-38.
  • 3Wang L,Basa NR,Shaikh A,et al.LPS inhibits fasted plasma Ghrelin levels in rats:role of IL-1 and PGs and functional implications[J].Am J Physiol Gastrointest Liver Physiol,2006,291(4):G611-620.
  • 4Lago F,Gonzalez-Juanatey JR,Casanueva FF,et al.Ghrelin,the same peptide for different functions:player or bystander?[J].Vitam Horm,2005,71(14):405-432.
  • 5Chen HY,Trumbauer ME,Chen AS,et al.Orexigenic action of peripheral Ghrelin is mediated by neuropeptide Y and agouti-related protein[J].Endocrinology,2004,145(6):2607-2612.
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  • 7le Roux CW,Neary NM,Halsey TJ,et al.Ghrelin does not stimulate food intake in patients with surgical procedures involving vagotomy[J].J Clin Endocrinol Metab,2005,90(8):4521-4524.
  • 8Arnold M,Mura A,Langhans W,et al.Gut vagal afferents are not necessary for the eating-stimulatory effect of intraperitoneally injected Ghrelin in the rat[J].J Neurosci,2006,26(43):11052-11060.
  • 9Zigman JM,Nakano Y,Coppari RA,et al.Mice lacking Ghrelin receptors resist the development of diet-induced obesity[J].J Clin Invest,2005,115(12):3564-3572.
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二级参考文献8

  • 1Zhang J V,Ren P G,Avsian-Kretchmer O,et al.Obestatin,a peptide encoded by the ghrelin gene,opposes ghrelin's effects on food intake[J].Science,2005,310:996-999.
  • 2Vivenza D,Rapa A,Castellino N,et al.Ghrelin gene polymorphisms and ghrelin,insulin,IGF-1,leptin and anthropometric data in children and adolescents[J].Eur J Endocrinol,2004,151:127-133.
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  • 4Szentirmai E,Hajdu I,Obal F Jr,et al.Ghrelin-induced sleep responses in ad libitum fed and food-restricted rats[J].Brain Res,2006,1088:131-140.
  • 5Kim M S,Ycon C Y,Jang P G,et al.The mitogenic and antiapoptotic actions of ghrelin in 3T3-L1 adipocytes[J].Mol Endocrinol,2004,18:2291-2301.
  • 6Gregoire F M,Smas C M,Sul H S.Understanding adipocyte differentiation[J].Physiol Rev,1998,78:783-809.
  • 7Catalan V,Gomez-Ambrosi J,Rotellar F,et al.The obestatin receptor (GPR39) is expressed in human adipose tissue and is down-regulated in obesity-associated type 2 diabetes mellitus[J].Clin Endocrinol,2007,66:598-601.
  • 8杨凌辉,邹大进.肥胖致胰岛素抵抗的机制[J].中华内分泌代谢杂志,2002,18(3):244-246. 被引量：82

共引文献11

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中国临床保健杂志
2011年 第2期

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