摘要
本文介绍了成组序贯试验的原理和方法。它可用于得到结果较慢（如数周或数月）及在整个试验过程中可分少数几个时间段来重复统计分析试验结果的情况。它既保留了传统序贯方法的优点又避免其局限性。当两种处理间确实存在差异时，它常可较早地得出结论，从而可减少样本量，缩短试验周期。特别在临床试验中它可尽早地使受试者停止接受较差的处理，符合伦理学的要求，同时又正好与临床试验中的期中分析相配合，可望有较大的发展前途。
This paper introduced .the principle and method of group sequential test, which can be used for cases in which responses may take long time to observe and the investigators wish to do repeated statistical analysis on only small number of occasions. It retains the advantages, but avoids the limitations of conventional sequential methods. It usually enables early termination of trials when the difference of two treatments exists, therefore it reduces sample size and shortens the period of trials. Especially. it makes the patients stop receiving wOrse treatment as early as possible in clinical trials, which satisfies the ethical considerations, and can well coordinate the interim analysis, so group sequential test has great expectations.
出处
《现代预防医学》
CAS
1999年第3期310-312,共3页
Modern Preventive Medicine
关键词
成组序贯试验
临床试验
期中分析
显著性检验
Group sequential test Clinical trial interim analysis sample size significance test
