摘要
目的了解该院近3年革兰阳性菌群分离率与药物敏感性变化,以促进本地区革兰阳性菌感染的预防与治疗。方法统计分析该院2006~2008年临床分离的革兰阳性菌的菌株分布及药物敏感性变化。结果 3年间革兰阳性菌以金黄色葡萄球菌、表皮葡萄球菌、溶血葡萄球菌为主。对各菌属的主要菌种进行药物敏感性分析,金黄色葡萄球菌、表皮葡萄球菌、溶血葡萄球菌对β-内酰胺类、大环内酯类、喹诺酮类、碳青霉烯类等抗生素都有较高的耐药性,连续3年耐甲氧西林金黄色葡萄球菌（MR-SA）的检出率分别为71%、62.8%和75%,对万古霉素、替考拉宁、利奈唑烷、褐霉素、奎奴普丁/达福普汀仍保持高度敏感。未出现对万古霉素耐药的葡萄球菌和肠球菌。结论 3年间阳性菌的检出率无明显波动,对抗生素的敏感性仍无明显变化,临床应合理使用抗生素,并加强对耐药菌株的监控。
Objective To understand the isolating rate and antibiotics sensibility of Gram-positive bacteria in our hospital in recent 3 years and to promote the precaution and therapy of Gram-positive bacteria infection.Methods To analyze the Gram-positive bacteria distribution and antibiotics sensibility in our hospital from 2006 to 2008.Results The main Gram-positive bacteria in these 3 years included Staphylococcus aureus（SA）,Staphylococcus epidermidis（SE）,Staphylococcus haematolysis（SH）.In antibiotics sensibility,SA,SE and SH kept the high resistance to β-lactams,macrocyclic lactone,quinolones and carbopenems antibiotics,the isolating rate of MRSA in the three years were 71%,62.8% and 75% which kept the high sensibility to vancomycin,teicoplanin,linezolid,fuscomycin and quinupristin/dalfopristin.Conclusion The isolating rate of Gram-positive did not fluctuate obviously,so did the sensibility to antibiotics.We should use antibiotics rationally and enhance monitoring drug resistant strains.
出处
《重庆医学》
CAS
CSCD
北大核心
2011年第14期1416-1418,共3页
Chongqing medicine
基金
国家科技支撑计划资助项目(2008BAI68B00)
关键词
革兰氏阳性菌
微生物药物敏感性试验
分离率
耐药性
Gram-positive bacteria
microbial sensitivity tests
isolating rate
drug resistance.
