摘要
目的探讨性激素变化与冠心病的关系。方法用放射免疫法和放射配体结合法分别测定36例男性冠心病患者性激素及白细胞性激素受体水平。并与24例健康男性作对照。结果男性冠心病患者血清雌二醇（E2）和睾酮（T）的比率及白细胞雌激素受体（ER）明显增加（P＜0．05），血清睾酮（T）、高密度脂蛋白胆固醇（HDL－C），载脂蛋白AI（APO－AI）和白细胞雄激素受体（AR）显著下降，且血清睾酮与高密度脂蛋白胆固醇呈正相关（P＜0．05）。白细胞雌激素受体及雄激素受体的亲和力（Kd）无明显变化（P＞0．05）。结论ER增高及雄性激素生物效应低下是男性冠心病的致病因子之一。
Objective To asses the relationship between sex hormone and coronary heart disease(CHD).Methods Sex hormone and sex hormone receptors in leukocytes were detected in male patients (n=36) with CHD. respectively by radioimmunoassay and radio - liganal - binding -assay. Resuts The ratio of serum eatrodial (E2) to testoaterone(T) and the estrogen receptors(ER) in leukocytes were remarkablely increased (P<0.05); The serum T. high - density lipoprotein cholestrol(HDL-C). APO-AI and androgen receptors (AR) in leukocytes were decreased significantly (P<0.05). The level of serum T was positively correlatedwith HDL- C. There were no changes in the affinity of sex hormone receptor (P>0.05). Conclusions The increase of ER and decrease of activity of testosterone was one of pathogenetic factors of male CHD.
出处
《新乡医学院学报》
CAS
1999年第3期237-239,共3页
Journal of Xinxiang Medical University
关键词
男性
冠心病
雄激素
性激素受体
male
coronary
heart disease
sex hormone
sex hormone receptor
