摘要
目的了解医院重症监护病房(ICU)病原菌的分布特点及耐药性,为临床合理使用抗菌药物提供理论依据。方法回顾性分析2007年1月-2009年12月医院ICU分离的514株病原菌的耐药性,细菌药物敏感性测定采用K-B纸片扩散法。结果 514株病原菌中革兰阴性杆菌377株,占73.35%,革兰阳性球菌75株,占14.59%,真菌62株,占12.06%;革兰阴性杆菌以鲍氏不动杆菌、铜绿假单胞菌、肺炎克雷伯菌、嗜麦芽寡养单胞菌、大肠埃希菌为主,革兰阳性球菌以耐甲氧西林金黄色葡萄球菌(MRSA)为主;各类病原菌对常用抗菌药物表现为严重耐药和多药耐药。结论 ICU分离病原菌耐药情况严重,病原菌分布及耐药性的监测对临床合理用药、降低医院感染率有重大的指导意义。
OBJECTIVE To investigate the common distribution and drug resistance of pathogenic bacteria of patients in intensive care unit,and provide theoretical bases for clinical rational use of antibiotics.METHODS The distribution and drug resistance of 514 strains isolated from patients in ICU from Jan 2007 to Dec 2009 were retrospectively analyzed.Drug sensitivity test was conducted based on disk diffusion testing（K-B）.RESULTS Among the 514 strains isolated from patients in ICU,the Gram-negative bacilli covered with 73.35%（377 strains）,Gram-positive cocci covered with 14.59%（75 strains）,and fungi covered with 12.06%（62 strains）.Acinetobacter baumannii,Pseudomonas aeruginosa,Klebsiella pneumoniae,Stenotrophomonas maltophiliaand Escherichia coli.were the main Gram-negative bacilli.Methicillin-resistant Staphylococcus aureuswas the main Gram-positive coccus.And the isolated bacteria showed serious multiple drug resistance to commonly used antibiotics.CONCLUSION The bacteria isolated from patients in ICU show serious drug resistance.Monitoring to the pathogenic distribution and drug resistance is of great significance for rational clinical use of antibiotics and reducing the nosocomial infection rate.
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2011年第9期1915-1917,共3页
Chinese Journal of Nosocomiology
关键词
重症监护病房
微生物学
耐药性
Intensive care unit
Microbiology
Drug resistance
