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肥胖的表观遗传跨代继承机制研究及运动干预的展望 被引量：1

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摘要 肥胖及其引发的代谢性疾病对人类的健康和生存构成重大威胁,是世界各国面临的最重要的社会问题之一。
作者 傅力
机构地区 天津医科大学康复与运动医学系
出处 《中国运动医学杂志》 CAS CSCD 北大核心 2011年第3期289-292,316,共5页 Chinese Journal of Sports Medicine
基金 国家自然科学基金(30871213) 天津市应用基础及前沿技术重点项目(09JCZD17400)资助
关键词 运动干预 表观遗传 肥胖 代谢性疾病 社会问题
分类号 R589.2 [医药卫生—内分泌] R87 [医药卫生—运动医学]
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参考文献42

  • 1Popkin BM. Will China's nutrition transition overwhelm its health care system and slow economic growth ? Health Affair, 2008, 27 (4): 1064-1076.
  • 2Franks PW, Hanson RL, Knowler WC, et al. Child- hood obesity, other cardiovascular risk factors and pre- mature death. N Engl J Med, 2010, 362 (6):485-493.
  • 3Ogden CL, Flegal KM, Carroll MD, et al. Prevalence and trends in overweight among US children and ado- lescents, 1999-2000. JAMA, 2002, 288 (14) : 1728- 1732.
  • 4Ogden CL, Carroll MD, Curtin LR, et al. Prevalence of overweight and obesity in the United States, 1999- 2004. JAMA, 2006, 295 (13): 1549-1555.
  • 5Nathanielsz PW, Poston L, Taylor PD. In utero exposure to maternal obesity and diabetes : animal models that identify and characterize implications for future health. ClinPerinatol, 2007, 34 (4):515-526.
  • 6McMillen IC, Robinson JS. Developmental origins of the metabolic syndrome : prediction, plasticity, and programming. Physiol Rev, 2005, 85 (2) : 571-633.
  • 7Guo F, Jen K-L. High-fat feeding during pregnancy and lactation affects offspring metabolism in rats. Physiol Behav, 1995, 57 (4) : 681-686.
  • 8Plagemann A. Perinatal programming and functional teratogenesis:impact on body weight regulation and obesity. Physiol Behav, 2005, 86 (5) : 661-668.
  • 9Bouret SG. Early life origins of obesity : role of hypothalamic programming. J Pediatr Gastroenterol Nutr, 2009, 48 (Suppl 1 ) : S31-S38.
  • 10Jirtle RL, Skinner MK. Environmental epigenomics and disease susceptibility. Nat. Rev. Genet, 2007, 8 (4) :253-262.

二级参考文献105

  • 1Cave H, Polak M, Drunat S, et al. Refinement of the 6q chromosomal region implicated in transient neonatal diabetes. Diabetes, 2000, 49: 108-113.
  • 2Temple IK, Shield JP. Transient neonatal diabetes: a disorder of imprinting. J Med Genet, 2002, 39: 872-875.
  • 3Arima T, Drewell RA, Arney KL, et al. A conserved imprinting control region at the HYMAI/ZAC domain is implicated in transient neonatal diabetes mellitus. Hum Mol Genet, 2001, 10: 1475 -1483.
  • 4Mackay DJ, Coupe AM, Shield JP, et al. Relaxation of imprinted expression of ZAC and HYMAI in a patient with transient neonatal diabetes mellitus. Hum Genet, 2002, 110: 139-144.
  • 5Julier C, Hyer RN, Davies J, et al. Insulin-IGF2 region on chromosome llp encodes a gene implicated in HLA-DR4- dependent diabetes susceptibility. Nature, 1991, 354: 155-159.
  • 6Polychronakos C, Kukuvitis A. Parental genomic imprinting in endocrinopathies. Eur J Endocrinol, 2002, 147: 561-569.
  • 7McCann JA, Xu YQ, Frechette R, et al. The insulin-like growth factor-II receptor gene is associated with type 1 diabetes: evidence of a maternal effect. J Clin Endocrinol Metab, 2004, 89: 5700- 5706.
  • 8Wu W, Shang J, Feng Y, et al. Identification of glucose- dependant insulin secretion targets in pancreatic beta cells by combining defined-mechanism compound library screening and siRNA gene silencing. J Biomol Screen, 2008, 13 : 128-134.
  • 9Marzban L, Tomas A, Becker TC, et al. Small interfering RNA- mediated suppression of proislet amyloid polypeptide expression inhibits islet amyloid formation and enhances survival of human islets in culture. Diabetes, 2008, 57 : 3045-3055.
  • 10Poy MN, Eliasson L, Krutzfeldt J, et al . A pancreatic isletspecific microRNA regulates insulin secretion. Nature, 2004, 432 : 226-230.

共引文献33

同被引文献31

  • 1Wenying Yang,Juming Lu,Jianping Weng,et al. Prevalence of diabetes among men and women in China. N Engl J Med,2010,362 : 1090 - 1101.
  • 2Kanai Y,Ushijima S,Kondo Y,et al. DNA methyltrans- ferase expression and DNA methylation of CpG island and pericentromeric satelliteregioninhumancolorectaland stom- ach cancers.Int J Cancer, 2001,91 : 205 - 212.
  • 3Rein T, DePamphilis ML,Zorbas H. Identifying 5-methyl- cytosine and related modifications in DNA genomes. Nucleic Acids Res, 1998,26 : 2255 - 2264.
  • 4Bird A. Katari S,Turan N,et al. DNA methylation and gene. Nature,2007,447:396 - 398.
  • 5Fraga MF, Ballestar E, Paz MF, et al. Epigenetic differences arise during the lifetime of monozygotic twins. Proc Natl Acad Sci USA, 2005,102 : 10604 - 10609.
  • 6Sutherland JE,Costa M. Epigenetics and the environment Aead Sci,2003,983 : 151 - 160.
  • 7Anway MD,Cupp AS,Uzumeu M,et al. Epigenetic trans- generational actions of endocrine disruptors and male fertility. Science ,2005,308 : 1466 - 1469.
  • 8Weaver IC,Cervoni N,Champagne FA,et al. Epigenetic programming by maternal behavior. Nat Neurosei,2004,7: 847 - 854.
  • 9Zhou SS, Zhou YM,Li D,et al: Dietary methyl-consuming compounds and metabolic syndrome. Hypertens Res, 2011,34(12) : 1239 - 1245.'.
  • 10Waterland RA. Do maternal methyl supplements in mice affect DNA methylation of offspring? J Nutr,2003,133: 238 - 239.

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中国运动医学杂志
2011年 第3期

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