摘要
目的:探讨氯吡格雷对急性心肌梗塞(AMI)患者炎症因子的影响。方法:入选我院心内科住院,且确诊为AMI患者50例,随机分为两组:A组:阿司匹林组25例,B组:阿司匹林加氯吡格雷组25例,分别测定两组用药前、后血清高敏C-反应蛋白(hs-CRP)、可溶性细胞间粘附分子-1(sICAM-1)水平,并作对比分析,另外选择我院健康体检者25例为C组(正常对照组)。结果:治疗前A组、B组较C组hs-CRP[(9.98±1.00)mg/L∶(10.33±0.79)mg/L∶(0.81±0.20)mg/L]、sICAM-1[(443.73±20.79)ng/ml∶(458.30±28.26)ng/ml∶(121.22±15.95)ng/ml]水平显著升高(P<0.01)。治疗7d后,A组、B组较治疗前hs-CRP[(6.69±0.73)mg/L∶(9.98±1.00)mg/L,(5.20±0.76)mg/L∶(10.33±0.79)mg/L]、sICAM-1[(273.71±12.48)ng/ml∶(443.73±20.79)ng/ml,(231.80±21.13)ng/ml∶(458.30±28.26)ng/ml]水平显著下降(P<0.01),且B组下降更显著(P<0.05)。结论:结果提示氯吡格雷可减轻动脉炎症反应,具有抗炎作用。
Objective：To explore effect of clopidogrel on levels of inflammatory factors in patients with acute myocardial infarction（AMI）.Methods：Fifty patients who were diagnosed as AMI in our hospital were enrolled in the study.They were randomly divided into two groups：Group A（aspirin group,n=25）,group B（aspirin plus clopidogrel group,n=25）.Another 25 normal persons were regard as normal control group.Levels of serum high sensitive C-reactive protein（hs-CRP） and soluble intercellular adhesion molecules-1（sICAM-1） were measured in three groups before and after treatment.The results were compared and analyzed later among three groups.Results：Before treatment,the hs-CRP levels in group A、B [（9.98±1.00） mg/L,（10.33±0.79） mg/L] significantly increased than that of group C [0.81±0.20） mg/L],the sICAM-1 levels in group A、B [（443.73±20.79） ng/ml,（458.30±28.26） ng/ml] also significantly increased compared with C group [（121.22±15.95） ng/ml],P0.01 all.After treatment 7d,levels of hs-CRP in group A、B [（6.69±0.73） mg/L,（5.20±0.76） mg/L]significantly decreased than before treatment[（9.98±1.00） mg/L,（10.33±0.79） mg/L],and sICAM-1 levels in group A、B [（273.71±12.48） ng/ml,（231.80±21.13） ng/ml]significantly decreased compared with before treatment [（443.73±20.79） ng/ml,（458.30±28.26） ng/ml],P0.01 all,and it＇s more significant in group B（P0.05）.Conclusion：The results suggest clopidogrel could reduce artery inflammatory reaction,possesses anti-inflammatory function.
出处
《心血管康复医学杂志》
CAS
2011年第2期148-151,共4页
Chinese Journal of Cardiovascular Rehabilitation Medicine
关键词
心肌梗塞
氯吡格雷
C反应蛋白质
细胞粘附分子
Myocardial infarction
Clopidogrel
C reactive protein
Cell adhesion molecule
