摘要
目的建立胱抑素C/肌酐比值的参考值范围以及在糖尿病肾病监测中的应用。方法检测120例健康人员和65例糖尿病患者的尿胱抑素C、肌酐、微量白蛋白、α1-微球蛋白等指标,按α1-MG的检测结果将糖尿病患者分为正常、升高两组,胱抑素C/肌酐比值参考值范围按CLSI C28-A2进行统计处理。结果胱抑素C/肌酐比值参考值范围为0.7~8.5 mg·mol-1CR,胱抑素C/肌酐比值在肾小管功能受损组显著升高（P〈0.01）。结论胱抑素C/肌酐比值有较高的灵敏度和特异性,是糖尿病肾病时肾小管功能障碍的敏感指标。
Aim To establish the reference interval of cystatin C/Cr ratio and to observe the application effect of cystatin C/Cr ratio in diabetic nephropathy.Methods 120 healthy persons and 65 diabetic patients were detected in urinary cystatin C,creatinine,microalbumin,α1-microglobulin and other indicators.According to the results of α1-MG diabetic patients were divided into normal and abnormal groups.Cystatin C/Cr ratio reference interval was established according to CLSI C28-A2.Results Cystatin C/Cr ratio reference interval was 0.7~8.5 mg·mol-1CR.Cystatin C/Cr in the renal tubular dysfunction group was significantly higher（P0.01）.Conclusion Cystatin C/Cr ratio was a sensitive and specific indicator for renal tubular dysfunction in diabetic nephropathy.
出处
《安徽医药》
CAS
2011年第4期457-458,共2页
Anhui Medical and Pharmaceutical Journal
基金
合肥市科技局自然科学研究资助项目(No200963)
