摘要
本实验应用了单独染镉和β－肾上腺素能受体阻断剂与镉联合作用两种动物模型，探讨了不同剂量镉对大鼠脾细胞β－肾上腺素能受体密度的影响，同时检测了Ｔ淋巴细胞亚群（ＣＤ＋４，ＣＤ＋８，ＣＤ＋４／ＣＤ＋８）和Ｔ淋巴细胞的增殖功能。结果表明镉可刺激并使脾细胞膜上的β－受体密度增加，镉对Ｔ细胞的免疫毒性表现为抑制Ｔ淋巴细胞的增殖功能，改变Ｔ细胞亚群的分型；而在β－受体被阻断后，镉的这种免疫毒性作用减轻：Ｔ淋巴细胞增殖功能不再受影响，Ｔ细胞亚群所受的影响也减少。因此，β－肾上腺素能受体机制可能是镉的细胞免疫毒性机制的一个重要部分。
Rats were given
cadmium(Cd) alone or Cd with beta antagonist in order to study the effect of Cd on β
adrenorecepter density of rat splenic cells.The subsets of T lymphocytes (CD + 4,CD + 8,CD
+ 4/CD + 8)and the proliferation of T lymphocytes were also detected. Cadmium alone
stimulated and increased β adrenorecepter density of rat splenic cell membrane.The
immunotoxicity of Cd showed that the proliferation of T lymphocytes was inhibited and the
subsets of T cells were changed. But in the animals with beta antagonist,the immunotoxicity of
Cd on T cells was decreased.It is concluded that β adrenorecepter may play an important role
in the mechanism of cadmium on cell immunotoxicity.
出处
《卫生研究》
CAS
CSCD
北大核心
1999年第4期203-205,共3页
Journal of Hygiene Research
基金
国家自然科学基金
