摘要
目的采用高频超声技术探讨冠心病患者心外膜脂肪（EAT）厚度与冠心病危险因素的相关性。方法84例患者根据冠脉造影结果分为冠脉正常组（28例）、冠心病单支病变组（28例）、冠心病多支病变组（28例），用高频超声分别测量EAT厚度和颈动脉IMT，将EAT厚度与颈动脉IMT等冠心病危险因素进行相关性分析。结果冠心病单支病变组及多支病变组EAT厚度及颈动脉IMT均明显高于冠脉正常组（P〈0．01）；单支病变组与多支病变组之间差异亦有统计学意义（P〈0．01）。EAT厚度与颈动脉IMT、年龄、体质量、腰围、体质量指数、低密度脂蛋白胆固醇、c反应蛋白呈正相关（r=0．124～0．790，P〈0．05或P〈0．01），与高密度脂蛋白胆固醇呈负相关（r=-0．203，P〈O．05）。冠脉正常组、冠心病单支病变组、冠心病多支病变组的EAT厚度与颈动脉IMT相关系数分别为0．678，0．713，0．737。结论在众多冠心病危险因素中，EAT厚度与颈动脉IMT相关性最强，并且冠心病程度越重，EAT与IMT的相关系数越高。EAT厚度可作为超声评价冠心病的一个测量指标。
Objective To explore the correlation between epicardial adipose tissue（EAT） thickness and cardiovascular risk factors in patients with coronary artery disease. Methods According to the results of coronary angiography,84 cases of patients undergone coronary angiography were divided into the normal control group（28 patients）, coronary artery disease group with single-vessel lesion （28 patients）, coronary artery disease group with multi-vessels lesion（28 patients）, respectively, then measured the EAT thickness and carotid intima-media thickness（IMT） by high-frequency ultrasound. A correlation analysis was carried out between the EAT and IMT and cardiovascular risk factors. Results In either coronary artery disease group with single-vessel lesion or multi-vessels lesion, the thicknesses of EAT and IMT were significantly higher than those in the normal control group（ P 〈0.01）, and the difference between group of single-vessel lesion and multi-vessels lesion was also statistically significant （ P ＂~0.01）. A correlation analysis between the EAT and IMT and cardiovascular risk factors showed that there were significantly positive correlations between EAT and the IMT, age, weight, waist circumference, body mass index, low-density lipoprotein, C- reactive protein （ r = 0. 124-0. 790, P 〈0.05 or P 〈0.01）, and the significantly negative correlation between EAT and high-density lipoprotein （ r = - 0. 203, P 〈0.05）. Correlation between EAT and the IMT was 0. 678,0. 713,0. 737 in the normal control group, group with single-vessel lesion, group with multi vessels lesion,respectively. Conclusions There were favorable correlation between EAT and carotid IMT in cardiovascular risk factors. The more severity of coronary heart disease, the more high correlations of EAT and IMT. EAT can be a valuable index in evaluating coronary artery disease.
出处
《中华超声影像学杂志》
CSCD
北大核心
2011年第3期197-200,共4页
Chinese Journal of Ultrasonography
关键词
超声检查
冠状动脉疾病
心外膜脂肪组织
颈动脉
内中膜厚度
Ultrasonography
Coronary disease
Epicardial adipose tissue
Carotid arteries
Intimamedia thickness
