摘要
目的:研究高压氧治疗脑挫裂伤前后患者免疫功能的变化。方法:免疫速率散射比浊法检测114例脑挫裂伤患者治疗前后血浆中C3、C4、IgG、IgA、IgM的变化,采用GCS评分标准判断疗效。结果:GCS评分,高压氧治疗组为12.95±1.96分,对照组为9.67±2.82分,差异有统计学意义(P<0.01)。补体水平,高压氧组治疗前C3、C4分别为0.97±0.28g/L与0.31±0.27g/L;治疗后C3、C4分别为1.20±0.23g/L与0.43±0.27g/L,差异统计学意义(P<0.01),对照组无统计学意义(P>0.05)。免疫球蛋白水平,高压氧治疗前后IgG、IgA、IgM差值分别为1.72±1.02g/L、0.22±0.26g/L、0.04±0.36g/L,差异有统计学意义(P<0.01)。结论:高压氧治疗脑挫裂伤能明显增强机体的免疫机能。
Objective:To study the changes of immune function of patients with cerebral contusion and laceration before and after Hyperbaric Oxygen (HBO) therapy.Methods:Of 114 cases with cerebral contusion and laceration,84 cases were treated with HBO,and 30 cases were treated by regular methods.C3、C4、IgG、IgA、IgM levels before and after treatment was measured with rate nepherometry.Treatment was evaluated by GCS scale.Results:Glasgow coma scale(GCS) was 12.95±1.96 after treatment in HBO groups(P<0.05),and in the control groups,the scale was 9.67±2.82(P<0.01);The values of C3、C4 before HBO was 0.97±0.28g/L,0.31±0.27g/L,after HBO treatment,the values of C3、C4 was 1.20±0.23g/L,0.43±0.27g/L(P<0.01).The minus-values of IgG、IgA、IgM before and after HBO treatment was 1.72±1.0g/L、0.22±0.26g/L、0.04±0.36g/L(P<0.01).Conclustons:The immune function of the cerebral contusion and laceration patients can be improved by HBO treatment.
关键词
高压氧
脑挫裂伤
免疫功能
Hyperbaric Oxygen
Cerebral contusion and laceration
Immunity
